An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation (Q39930107)

15 September 2017

An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation (English)

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15 September 2017

5

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15 September 2017

F Talotta

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15 September 2017

A Cimmino

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15 September 2017

M R Matarazzo

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15 September 2017

L Casalino

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15 September 2017

M D'Esposito

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15 September 2017

R Di Lauro

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15 September 2017

P Verde

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15 September 2017

language of work or name

English

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publication date

13 October 2008

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15 September 2017

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28

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73-84

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https://scigraph.springernature.com/pub.10.1038/onc.2008.370

15 September 2017

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Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis.

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MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

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Critical regulation of genes for tumor cell migration by AP-1.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Cell cycle-dependent variations in c-Jun and JunB phosphorylation: a role in the control of cyclin D1 expression.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Promoter specificity and biological activity of tethered AP-1 dimers

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNAs: genomics, biogenesis, mechanism, and function

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA signatures in human cancers

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Accumulation of Fra-1 in ras-transformed cells depends on both transcriptional autoregulation and MEK-dependent posttranslational stabilization

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

miR-15 and miR-16 induce apoptosis by targeting BCL2

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

SMAD proteins control DROSHA-mediated microRNA maturation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Dose-dependent inhibition of thyroid differentiation by RAS oncogenes

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

AP-1: a double-edged sword in tumorigenesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

LNA-mediated microRNA silencing in non-human primates

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Oncomirs - microRNAs with a role in cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Putative promoter regions of miRNA genes involved in evolutionarily conserved regulatory systems among vertebrates.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

The role of microRNA genes in papillary thyroid carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

The guardian's little helper: microRNAs in the p53 tumor suppressor network

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

c-Jun promotes cellular survival by suppression of PTEN.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA gene expression deregulation in human breast cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

A mammalian microRNA expression atlas based on small RNA library sequencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Transformation by ras modifies AP1 composition and activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

c-Myc-regulated microRNAs modulate E2F1 expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Transcription factors control invasion: AP-1 the first among equals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA deregulation in human thyroid papillary carcinomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

AP-1 as a regulator of cell life and death

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.370

miR-21-mediated tumor growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

A microRNA expression signature of human solid tumors defines cancer gene targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Downregulation of tumor suppressor Pdcd4 promotes invasion and activates both beta-catenin/Tcf and AP-1-dependent transcription in colon carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA signature predicts survival and relapse in lung cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.370

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.370

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15 September 2017

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