Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis (Q39946627)

15 September 2017

Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis (English)

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15 September 2017

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Mark Simmonds

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15 September 2017

Alan Storey

series ordinal

2

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15 September 2017

language of work or name

English

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publication date

1 November 2008

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International Journal of Cancer

15 September 2017

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15 September 2017

123

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15 September 2017

10

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15 September 2017

2260-2266

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describes a project that uses

15 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2677715/fullTextXML

inferred from PubMed Central ID database lookup

cites work

HPV E6 degradation of p53 and PDZ containing substrates in an E6AP null background

1 reference

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BH3-only proteins trigger cytochrome c release, but how?

22 September 2017

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Role of HPV E6 proteins in preventing UVB-induced release of pro-apoptotic factors from the mitochondria

22 September 2017

1 reference

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The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

22 September 2017

1 reference

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Role of Bax and Bak in mitochondrial morphogenesis

22 September 2017

1 reference

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Clinicopathologic features of skin cancer in organ transplant recipients: a retrospective case-control series.

22 September 2017

1 reference

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HPV-associated skin disease.

22 September 2017

1 reference

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

22 September 2017

1 reference

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Repair of UV-induced thymine dimers is compromised in cells expressing the E6 protein from human papillomaviruses types 5 and 18.

22 September 2017

1 reference

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

22 September 2017

1 reference

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

22 September 2017

1 reference

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

22 September 2017

1 reference

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Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

22 September 2017

1 reference

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Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

22 September 2017

1 reference

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

22 September 2017

1 reference

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Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Inhibition of Bak-induced apoptosis by HPV-18 E6.

22 September 2017

1 reference

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Genetic heterogeneity of oncogenic human papillomavirus type 5 (HPV5) and phylogeny of HPV5 variants associated with epidermodysplasia verruciformis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

22 September 2017

1 reference

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22 September 2017

1 reference

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

22 September 2017

1 reference

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A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

E6 proteins from diverse cutaneous HPV types inhibit apoptosis in response to UV damage

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

DNA damage in human B cells can induce apoptosis, proceeding from G1/S when p53 is transactivation competent and G2/M when it is transactivation defective.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Two pathways for induction of apoptosis by ultraviolet radiation in cultured human keratinocytes.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Sunlight exposure and (sero)prevalence of epidermodysplasia verruciformis-associated human papillomavirus

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677715

In vitro expressed HPV 8 E6 protein does not bind p53

20 August 2018

1 reference

12 December 2020

Sunburn and p53 in the onset of skin cancer

1 reference

12 December 2020

Ultraviolet-B-Induced Apoptosis of Keratinocytes: Evidence for Partial Involvement of Tumor Necrosis Factor-α in the Formation of Sunburn Cells

1 reference

12 December 2020

Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes

1 reference

12 December 2020

Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirus-mediated pathogenesis

1 reference

12 December 2020

Identifiers

DOI

10.1002/IJC.23815

1 reference

15 September 2017

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15 September 2017

PubMed publication ID

18752251

1 reference