The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer. (Q39996855)

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English	The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.	scientific article

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5 January 2020

The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer (English)

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Jhao-Hao Hong

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Lyu-Han Wang

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Yun-Wei Lin

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4 March 2008

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Experimental Cell Research

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1881-1891

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Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists

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Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer

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Epidermal growth factor-related peptides and their receptors in human malignancies

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The relationship of quantitative epidermal growth factor receptor expression in non-small cell lung cancer to long term survival

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Epidermal growth factor receptor tyrosine kinase as a target for anticancer therapy

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The epidermal growth factor receptor as a target for cancer therapy

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway

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Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells

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Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

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Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

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Role of the human RAD51 protein in homologous recombination and double-stranded-break repair.

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BRCA2-dependent and independent formation of RAD51 nuclear foci.

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Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer

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Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas

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Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

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DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma

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Homologous recombinational repair vis-à-vis chlorambucil resistance in chronic lymphocytic leukemia

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Gene expression in tumor-adjacent normal tissue is associated with recurrence in patients with rectal cancer treated with adjuvant chemoradiation

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High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients

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Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer

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p38 MAP kinases: beyond the stress response

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Mammalian MAP kinase signalling cascades

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

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Repair of DNA lesions induced by polycyclic aromatic hydrocarbons in human cell-free extracts: involvement of two excision repair mechanisms in vitro.

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p53 mutations, benzo[a]pyrene and lung cancer.

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Fifty years of benzo(a)pyrene

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Chemical and mutagenic specificities of polycyclic aromatic hydrocarbon carcinogens.

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DNA adducts of chemical carcinogens

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Gene expression profiles and genetic damage in benzo(a)pyrene diol epoxide-exposed TK6 cells

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Induction of cell death, DNA strand breaks, and cell cycle arrest in DU145 human prostate carcinoma cell line by benzo[a]pyrene and benzo[a]pyrene-7,8-diol-9,10-epoxide

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PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells

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Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation: role of p38 MAP kinase

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Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression

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Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51

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Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment

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Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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RAD51 is involved in repair of damage associated with DNA replication in mammalian cells

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Elevated recombination in immortal human cells is mediated by HsRAD51 recombinase

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10.1016/J.YEXCR.2008.02.013

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5 January 2020

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Europe PubMed Central

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