A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood. (Q40099738)

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scientific article published on 24 June 2016

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English	A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood.	scientific article published on 24 June 2016

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scholarly article

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15 March 2020

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood (English)

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15 March 2020

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Cecilia S. Lindestam Arlehamn

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Daniela Weiskopf

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Ricardo da Silva Antunes

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Colin Havenar-Daughton

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Samantha M Reiss

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Samantha M Reiss

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Matthew Brigger

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Matthew Brigger

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Marcella Bothwell

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Alessandro Sette

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Shane Crotty

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24 June 2016

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15 March 2020

Journal of Immunology

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983-993

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15 March 2020

Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique

1 reference

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CXCL13 is a plasma biomarker of germinal center activity

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Sustained Transmission of Pertussis in Vaccinated, 1-5-Year-Old Children in a Preschool, Florida, USA.

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HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.

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Dynamics of B cells in germinal centres

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Follicular helper T cell signature in type 1 diabetes

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ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism

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T follicular helper cell differentiation, function, and roles in disease

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T-cell immunity to infection with dengue virus in humans

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Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses

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T follicular helper cell dynamics in germinal centers

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CD4⁺ follicular helper T cell infiltration predicts breast cancer survival

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The good, the bad and the ugly - TFH cells in human health and disease

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Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

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Inadequate T follicular cell help impairs B cell immunity during HIV infection.

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Molecular mechanisms of T cell co-stimulation and co-inhibition

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Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

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Expansion of HIV-specific T follicular helper cells in chronic HIV infection

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T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts

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Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ)

1 reference

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Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation

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Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation

1 reference

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22 September 2017

STAT5 is a potent negative regulator of TFH cell differentiation

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22 September 2017

Germinal centers

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A novel assay for detection of hepatitis C virus-specific effector CD4(+) T cells via co-expression of CD25 and CD134.

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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

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Phenotype, effector function, and tissue localization of PD-1-expressing human follicular helper T cell subsets

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Follicular helper CD4 T cells (TFH)

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Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

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Control of immunity by the TNFR-related molecule OX40 (CD134)

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

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Cytokine-secreting follicular T cells shape the antibody repertoire

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1 reference

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High levels of human antigen-specific CD4+ T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40).

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The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4955771

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T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/27342848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duration of protection after first dose of acellular pertussis vaccine in infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/27342848

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1600318

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27342848%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference

Europe PubMed Central

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15 March 2020

1 reference

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15 March 2020

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