Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases (Q35934211)

11 August 2017

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title

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases (English)

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11 August 2017

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Dennis J Selkoe

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11 August 2017

1 November 2004

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11 August 2017

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11 August 2017

6

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11 August 2017

1054-1061

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11 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/ncb1104-1054

11 August 2017

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cites work

Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Proteolytic fragments of Alzheimer's paired helical filaments.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Neurodegenerative tauopathies

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

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https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

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https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Inflammation, autotoxicity and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Molecular Pathways of Neurodegeneration in Parkinson's Disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Genetics of Parkinson's disease and biochemical studies of implicated gene products

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Targeting programmed cell death in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The ubiquitin pathway in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

The 1.6-A crystal structure of the class of chaperones represented by Escherichia coli Hsp31 reveals a putative catalytic triad

1 reference

https://api.crossref.org/works/10.1038%2FNCB1104-1054

7 January 2021

Identifiers

DOI

10.1038/NCB1104-1054

1 reference

PubMed ID

15516999

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15516999