The rapid activation of protein synthesis by growth hormone requires signaling through mTOR. (Q40173852)

18 September 2017

The rapid activation of protein synthesis by growth hormone requires signaling through mTOR. (English)

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18 September 2017

2

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18 September 2017

Amanda A Hayashi

1

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18 September 2017

6 February 2007

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American Journal of Physiology - Endocrinology and Metabolism

18 September 2017

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18 September 2017

292

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18 September 2017

6

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18 September 2017

E1647-55

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

18 September 2017

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Rapid activation of MAP kinase and S6 kinase by growth hormone in 3T3-F442A preadipocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Growth hormone activates mitogen-activated protein kinase and S6 kinase and promotes intracellular tyrosine phosphorylation in 3T3-F442A preadipocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Regulation of peptide-chain elongation in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Functional properties of phosphorylated elongation factor 2

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Signalling pathway of GH.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat epididymal fat-cells

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The role of STAT proteins in growth hormone signaling

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Rheb fills a GAP between TSC and TOR.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Drosophila S6 kinase: a regulator of cell size

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

In vivo analysis of growth hormone receptor signaling domains and their associated transcripts

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Growing roles for the mTOR pathway

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Signaling molecules involved in coupling growth hormone receptor to mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Regulation of the phosphorylation of elongation factor 2 by MEK-dependent signalling in adult rat cardiomyocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

The mTOR pathway in the control of protein synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00674.2006

10.1152/AJPENDO.00674.2006

21 January 2018

Identifiers

DOI

1 reference

18 September 2017

1 reference

PubMed ID

17284572