Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line (Q40184671)

18 September 2017

title

Tissue-specific transcription factor HNF4alpha inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 beta-cell line (English)

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18 September 2017

6

Ludger Klein-Hitpass

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18 September 2017

Silke Erdmann

1

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18 September 2017

Sabine Senkel

2

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18 September 2017

Tanja Arndt

3

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18 September 2017

Belén Lucas

4

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18 September 2017

Jörn Lausen

5

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18 September 2017

Gerhart U Ryffel

7

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18 September 2017

Heike Thomas

8

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18 September 2017

publication date

1 January 2007

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18 September 2017

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18 September 2017

volume

388

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18 September 2017

issue

1

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18 September 2017

page(s)

91-106

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Gene ontology: tool for the unification of biology

18 September 2017

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos

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Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells

21 January 2018

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Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator

21 January 2018

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Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms.

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Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

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Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.

21 January 2018

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The activation function-1 of hepatocyte nuclear factor-4 is an acidic activator that mediates interactions through bulky hydrophobic residues

21 January 2018

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RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

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An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young

21 January 2018

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Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line

21 January 2018

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Expression of HNF4alpha isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3' end splicing

21 January 2018

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Developmentally regulated N-terminal variants of the nuclear receptor hepatocyte nuclear factor 4alpha mediate multiple interactions through coactivator and corepressor-histone deacetylase complexes

21 January 2018

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C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4

21 January 2018

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FLP and Cre recombinase function in Xenopus embryos

21 January 2018

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DNA binding is required for the apoptogenic action of apoptosis inducing factor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1515/BC.2007.011

1 reference

18 September 2017

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