Context-dependent dysregulation of transcription by mutant huntingtin (Q40225463)

18 September 2017

title

Context-dependent dysregulation of transcription by mutant huntingtin (English)

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18 September 2017

Jonathan Cornett

1

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18 September 2017

Lauren Smith

2

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18 September 2017

Meyer Friedman

3

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18 September 2017

Ji-Yeon Shin

4

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18 September 2017

Xiao-Jiang Li

5

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18 September 2017

Shi-Hua Li

6

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18 September 2017

language of work or name

English

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publication date

29 September 2006

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Journal of Biological Chemistry

18 September 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

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18 September 2017

volume

281

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18 September 2017

issue

47

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18 September 2017

page(s)

36198-36204

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

18 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Nuclear targeting of mutant Huntingtin increases toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Transcriptional dysregulation in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Transcriptional abnormalities in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Interaction of Huntington disease protein with transcriptional activator Sp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

1 reference

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Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

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Neurodegenerative disease: cut to the chase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Polyglutamine expansion of huntingtin impairs its nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice

21 January 2018

1 reference

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Regulation of the rat p75 neurotrophin receptor promoter by GC element binding proteins

21 January 2018

1 reference

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Sp1 binding is critical for promoter assembly and activation of the MCP-1 gene by tumor necrosis factor

21 January 2018

1 reference

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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607839200

21 January 2018

Identifiers

DOI

10.1074/JBC.M607839200

1 reference

release_sjx3o2nodfafhp42p3pzd4bhea

18 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sjx3o2nodfafhp42p3pzd4bhea

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference