Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway (Q40230307)

18 September 2017

Apoptosis induced by proteasome inhibition in cancer cells: predominant role of the p53/PUMA pathway (English)

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18 September 2017

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18 September 2017

C Bonner

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author name string

C G Concannon

1

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18 September 2017

B F Koehler

2

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18 September 2017

Claus Reimertz

3

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18 September 2017

B M Murphy

4

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18 September 2017

N Thurow

6

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18 September 2017

M W Ward

7

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18 September 2017

A Villunger

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18 September 2017

D Kögel

10

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18 September 2017

J H M Prehn

11

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18 September 2017

language of work or name

English

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publication date

18 September 2006

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18 September 2017

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18 September 2017

26

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18 September 2017

12

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18 September 2017

1681-1692

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209974

18 September 2017

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Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction

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Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes

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Proteasome inhibition in multiple myeloma: therapeutic implication

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Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

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Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons

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Protease inhibitors restore radiation-induced apoptosis to Bcl-2-expressing lymphoma cells

21 January 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

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Proteasomes modulate balance among proapoptotic and antiapoptotic Bcl-2 family members and compromise functioning of the electron transport chain in leukemic cells

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Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

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Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity

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PUMA, a novel proapoptotic gene, is induced by p53

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Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

21 January 2018

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

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Apoptosis induction resulting from proteasome inhibition

21 January 2018

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Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

21 January 2018

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Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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Proteasome inhibitors induce p53/p21-independent apoptosis in human glioma cells

21 January 2018

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Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.

21 January 2018

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21 January 2018

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Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite

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Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination

21 January 2018

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Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM).

21 January 2018

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PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

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PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

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Identifiers

DOI

10.1038/SJ.ONC.1209974

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Dimensions Publication ID

18 September 2017

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