Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53. (Q40318210)

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16 January 2020

title

Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53 (English)

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16 January 2020

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1

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16 January 2020

John G Hay

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16 January 2020

author name string

T Pipiya

2

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16 January 2020

S Chen

3

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16 January 2020

S Heitner

4

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16 January 2020

J Cheng

5

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16 January 2020

Y Q Huang

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16 January 2020

W N Rom

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16 January 2020

language of work or name

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10 February 2006

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16 January 2020

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16 January 2020

volume

13

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16 January 2020

issue

7

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16 January 2020

page(s)

686-695

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https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700936

16 January 2020

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Adenovirus-mediated delivery of p53 results in substantial apoptosis to myeloma cells and is not cytotoxic to flow-sorted CD34(+) hematopoietic progenitor cells and normal lymphocytes

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Regulation of p53 stability by Mdm2

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Mdm2 promotes the rapid degradation of p53

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Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

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Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

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Identifiers

DOI

10.1038/SJ.CGT.7700936

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16470212%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

16 January 2020

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