Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase (Q40341746)

19 September 2017

Differential regulation of cardiomyocyte survival and hypertrophy by MDM2, an E3 ubiquitin ligase (English)

1 reference

19 September 2017

Ambrus Toth

1

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19 September 2017

Philip Nickson

series ordinal

2

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19 September 2017

Liu Liang Qin

series ordinal

3

1 reference

19 September 2017

Peter Erhardt

series ordinal

4

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19 September 2017

language of work or name

English

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publication date

8 December 2005

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Journal of Biological Chemistry

19 September 2017

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19 September 2017

281

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19 September 2017

6

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19 September 2017

3679-3689

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Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

19 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

The p53 pathway: positive and negative feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Akt activation induced by an antioxidant compound during ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

The role of p53 in hypoxia-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Enhanced expression of p53 and apoptosis induced by blockade of the vacuolar proton ATPase in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

The mitochondrial death pathway and cardiac myocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

p73 and p63 protein stability: the way to regulate function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Apoptotic and growth-promoting activity of E2F modulated by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: implications for herceptin-induced cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Small molecule inhibitors of p53/MDM2 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Cardiac hypertrophy served with protein kinase Cepsilon: delta isoform substitution available at additional cost

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

Inhibitors of protein kinase signaling pathways: emerging therapies for cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M509630200

21 January 2018

Identifiers

DOI

10.1074/JBC.M509630200

1 reference

19 September 2017

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