Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy. (Q40354154)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

Santiago Rodriguez-Ospina

29 February 2020

author

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Marcia N Gordon

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Jerry B Hunt

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Kevin R Nash

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Devon Placides

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Peter Moran

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Maj-Linda B Selenica

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Firas Abuqalbeen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Kevin Ratnasamy

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Nina Slouha

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Miloni Savlia

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Yashobha Ranaweera

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Patrick Reid

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Chad A Dickey

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Rodrigo Uricia

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Clement G Y Yang

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Leslie A Sandusky

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Dave Morgan

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Daniel C Lee

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

language of work or name

English

0 references

publication date

1 November 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

published in

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

14842-14860

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination.

29 February 2020

cites work

1 reference

12 December 2020

Neurodegenerative tauopathies

1 reference

12 December 2020

Expression of arginase isozymes in mouse brain

1 reference

12 December 2020

Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

1 reference

12 December 2020

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

1 reference

12 December 2020

Arginase expression in mouse embryonic development.

1 reference

12 December 2020

Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro.

1 reference

12 December 2020

TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism.

1 reference

12 December 2020

Widespread expression of arginase I in mouse tissues. Biochemical and physiological implications

1 reference

12 December 2020

Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62.

1 reference

12 December 2020

Phosphorylation of tau by fyn: implications for Alzheimer's disease.

1 reference

12 December 2020

Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

1 reference

12 December 2020

Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation

1 reference

12 December 2020

Cysteine oxidation of tau and microtubule-associated protein-2 by peroxynitrite: modulation of microtubule assembly kinetics by the thioredoxin reductase system

1 reference

12 December 2020

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

1 reference

12 December 2020

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

1 reference

12 December 2020

The chemokine system in diverse forms of macrophage activation and polarization

1 reference

12 December 2020

Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo

1 reference

12 December 2020

Role of Interleukin-4 in Regulation of Age-related Inflammatory Changes in the Hippocampus

1 reference

12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

12 December 2020

Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads.

1 reference

12 December 2020

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

1 reference

12 December 2020

Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein

1 reference

12 December 2020

TOR signaling in growth and metabolism

1 reference

12 December 2020

Ornithine deficiency in the arginase double knockout mouse

1 reference

12 December 2020

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

1 reference

12 December 2020

Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.

1 reference

12 December 2020

Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint.

1 reference

12 December 2020

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

1 reference

12 December 2020

Microglial activation is required for Abeta clearance after intracranial injection of lipopolysaccharide in APP transgenic mice.

1 reference

12 December 2020

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease

1 reference

12 December 2020

Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs

1 reference

12 December 2020

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 reference

12 December 2020

A possible link between astrocyte activation and tau nitration in Alzheimer's disease.

1 reference

12 December 2020

Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin

1 reference

12 December 2020

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

1 reference

12 December 2020

Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.

1 reference

12 December 2020

Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy

1 reference

12 December 2020

Alternative activation of macrophages: an immunologic functional perspective

1 reference

12 December 2020

Alternative activation of macrophages: immune function and cellular biology

1 reference

12 December 2020

Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo.

1 reference

12 December 2020

Induction of autophagy by spermidine promotes longevity

1 reference

12 December 2020

A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway

1 reference

12 December 2020

Spermidine: a novel autophagy inducer and longevity elixir

1 reference

12 December 2020

Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol

1 reference

12 December 2020

Caspase activation precedes and leads to tangles

1 reference

12 December 2020

Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats

1 reference

12 December 2020

Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation

1 reference

12 December 2020

Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma

1 reference

12 December 2020

A caspase cleaved form of tau is preferentially degraded through the autophagy pathway

1 reference

12 December 2020

A central role for polyamines in microtubule assembly in cells.

1 reference

12 December 2020

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

1 reference

12 December 2020

CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.

1 reference

12 December 2020

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

1 reference

12 December 2020

The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium.

1 reference

12 December 2020

Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies

1 reference

12 December 2020

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

1 reference

12 December 2020

The acetylation of tau inhibits its function and promotes pathological tau aggregation

1 reference

12 December 2020

RNA interference of argininosuccinate synthetase restores sensitivity to recombinant arginine deiminase (rADI) in resistant cancer cells

1 reference

12 December 2020

Longevity-relevant regulation of autophagy at the level of the acetylproteome.

1 reference

12 December 2020

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

1 reference

12 December 2020

Tyrosine nitration within the proline-rich region of Tau in Alzheimer's disease

1 reference

12 December 2020

Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines

1 reference

12 December 2020

A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death

1 reference

12 December 2020

Polyamines in aging and disease

1 reference

12 December 2020

Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation

1 reference

12 December 2020

Selective tau tyrosine nitration in non-AD tauopathies

1 reference

12 December 2020

Deprivation of arginine by recombinant human arginase in prostate cancer cells

1 reference

12 December 2020

Hyperphosphorylation and cleavage at D421 enhance tau secretion

1 reference

12 December 2020

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies

1 reference

12 December 2020

Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies

1 reference

12 December 2020

Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology

1 reference

12 December 2020

Microglia: actively surveying and shaping neuronal circuit structure and function.

1 reference

12 December 2020

Effect of stroke on arginase expression and localization in the rat brain.

1 reference

12 December 2020

Microglia: new roles for the synaptic stripper.

1 reference

12 December 2020

Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

1 reference

12 December 2020

Aging enhances classical activation but mitigates alternative activation in the central nervous system

1 reference

12 December 2020

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model

1 reference

12 December 2020

Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice

1 reference

12 December 2020

Transglutaminase and polyamination of tubulin: posttranslational modification for stabilizing axonal microtubules

1 reference

12 December 2020

Giardia duodenalis arginine deiminase modulates the phenotype and cytokine secretion of human dendritic cells by depletion of arginine and formation of ammonia.

1 reference

12 December 2020

Natural polyamine inhibits mouse skin inflammation and macrophage activation

1 reference

12 December 2020

Microglia and synapse interactions: fine tuning neural circuits and candidate molecules

1 reference

12 December 2020

Arginase and Arginine Decarboxylase - Where Do the Putative Gate Keepers of Polyamine Synthesis Reside in Rat Brain?

1 reference

12 December 2020

Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research.

1 reference

12 December 2020

Synthetic polyamines activating autophagy: effects on cancer cell death

1 reference

12 December 2020

Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

1 reference

12 December 2020

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

1 reference

12 December 2020

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

1 reference

12 December 2020

Diversity of amino acid signaling pathways on autophagy regulation: a novel pathway for arginine

1 reference

12 December 2020

NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.

1 reference

12 December 2020

Altered arginine metabolism in Alzheimer's disease brains.

1 reference

12 December 2020

Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation

1 reference

12 December 2020

Arginase I, Polyamine, and Prostaglandin E2Pathways Suppress the Inflammatory Response and Contribute to Diffuse Cutaneous Leishmaniasis

1 reference

12 December 2020

The physiology and pathology of microtubule-associated protein tau.

1 reference

12 December 2020

Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker.

1 reference

12 December 2020

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.

1 reference

12 December 2020

Pathological interface between oligomeric alpha-synuclein and tau in synucleinopathies

1 reference

12 December 2020

Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Polyamines in mammalian ageing: an oncological problem, too? A review

1 reference

12 December 2020

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

1 reference

12 December 2020

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

1 reference

12 December 2020

10.1523/JNEUROSCI.3959-14.2015

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26538654%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

26538654

1 reference