Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects (Q40385272)

20 September 2017

Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects (English)

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human subject research project

20 September 2017

Plasmodium falciparum

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author

Sebastian A. Mikolajczak

object named as

Sebastian A Mikolajczak

2

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Stefan H I Kappe

18

object named as

Stefan H I Kappe

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20 September 2017

15

Ashley M Vaughan

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20 September 2017

4

Matt E Fishbaugher

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20 September 2017

13

Dorender A Dankwa

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20 September 2017

16

D Noah Sather

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20 September 2017

3

Brandon K Sack

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20 September 2017

1

James G Kublin

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20 September 2017

5

Annette Seilie

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20 September 2017

6

Lisa Shelton

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20 September 2017

Tracie VonGoedert

7

1 reference

20 September 2017

Melike Firat

8

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20 September 2017

Sara Magee

9

1 reference

20 September 2017

Emma Fritzen

10

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20 September 2017

Will Betz

11

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20 September 2017

Heather S Kain

12

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20 September 2017

Ryan W J Steel

14

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20 September 2017

Sean C Murphy

17

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20 September 2017

language of work or name

English

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publication date

1 January 2017

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Science Translational Medicine

20 September 2017

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20 September 2017

9

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20 September 2017

371

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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

20 September 2017

1 reference

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Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure

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1 reference

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Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei

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1 reference

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Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Protection against a malaria challenge by sporozoite inoculation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Genetic engineering of attenuated malaria parasites for vaccination

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Novel approaches to whole sporozoite vaccination against malaria.

21 January 2018

1 reference

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A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion

21 January 2018

1 reference

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Susceptibility to Plasmodium yoelii Preerythrocytic Infection in BALB/c Substrains Is Determined at the Point of Hepatocyte Invasion

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1 reference

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First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

21 January 2018

1 reference

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Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

21 January 2018

1 reference

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Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

21 January 2018

1 reference

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Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum

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1 reference

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A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle

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Immune mechanisms in malaria: new insights in vaccine development

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Advances and challenges in malaria vaccine development.

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1 reference

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Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals

21 January 2018

1 reference

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The RTS,S vaccine candidate for malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Direct microscopic quantification of dynamics of Plasmodium berghei sporozoite transmission from mosquitoes to mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Pre-erythrocytic antibody profiles induced by controlled human malaria infections in healthy volunteers under chloroquine prophylaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics

21 January 2018

1 reference

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Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Protracted protection to Plasmodium berghei malaria is linked to functionally and phenotypically heterogeneous liver memory CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Safety and comparability of controlled human Plasmodium falciparum infection by mosquito bite in malaria-naïve subjects at a new facility for sporozoite challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines

21 January 2018

1 reference

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Laser cutting eliminates nucleic acid cross-contamination in dried-blood-spot processing

21 January 2018

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Improving the expression of recombinant soluble HIV Envelope glycoproteins using pseudo-stable transient transfection

21 January 2018

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Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies

21 January 2018

1 reference

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Development of a quantitative flow cytometry-based assay to assess infection by Plasmodium falciparum sporozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9099

10.1126/SCITRANSLMED.AAD9099

21 January 2018

Identifiers

DOI

1 reference

20 September 2017

1 reference