Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models (Q40392026)

20 September 2017

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models (English)

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20 September 2017

Mitsuaki Fujimoto

1

1 reference

20 September 2017

Eiichi Takaki

2

1 reference

20 September 2017

Tetsuya Hayashi

3

1 reference

20 September 2017

Yasushi Kitaura

4

1 reference

20 September 2017

Yasunori Tanaka

5

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20 September 2017

Sachiye Inouye

6

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20 September 2017

Akira Nakai

7

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20 September 2017

language of work or name

English

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publication date

28 July 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

41

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20 September 2017

34908-34916

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

The Hsp70 and Hsp60 chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Bacterial and yeast chaperones reduce both aggregate formation and cell death in mammalian cell models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Analysis of heat shock transcription factor for suppression of polyglutamine toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Cloning of a cDNA for heat-shock protein hsp40, a human homologue of bacterial DnaJ

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Hsp25, a member of the Hsp30 family, promotes inclusion formation in response to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

HSF4 is required for normal cell growth and differentiation during mouse lens development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Feeding induces expression of heat shock proteins that reduce oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Phosphorylation of alphaB-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Muscle fiber types: how many and what kind?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Modulation of tolerance by mutant heat shock transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Multiple layers of regulation of human heat shock transcription factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Formation of polyglutamine inclusions in non-CNS tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Inclusion formation in Huntington's disease R6/2 mouse muscle cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Impaired IgG production in mice deficient for heat shock transcription factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M506288200

21 January 2018

Identifiers

DOI

10.1074/JBC.M506288200

1 reference

20 September 2017

1 reference