The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment. (Q40400095)

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30 December 2019

title

The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment (English)

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30 December 2019

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30 December 2019

Alice Rothnie

1

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30 December 2019

Roisin Mcmahon

3

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30 December 2019

Richard Callaghan

6

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30 December 2019

author name string

Janet Storm

2

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30 December 2019

Andrew Taylor

4

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30 December 2019

language of work or name

English

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publication date

1 July 2005

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30 December 2019

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30 December 2019

volume

579

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30 December 2019

issue

18

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30 December 2019

page(s)

3984-3990

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Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

30 December 2019

cites work

1 reference

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Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

21 January 2018

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Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 January 2018

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P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

21 January 2018

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Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.

21 January 2018

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Dissection of drug-binding-induced conformational changes in P-glycoprotein.

21 January 2018

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P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity

21 January 2018

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Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis

21 January 2018

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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

21 January 2018

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Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

21 January 2018

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The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.

21 January 2018

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Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

21 January 2018

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Further characterization of the sixth transmembrane domain of Pgp1 by site-directed mutagenesis

21 January 2018

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Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein

21 January 2018

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Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein

21 January 2018

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RETRACTED: Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters

21 January 2018

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Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine

21 January 2018

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P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

21 January 2018

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Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

21 January 2018

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Secondary and tertiary structure changes of reconstituted LmrA induced by nucleotide binding or hydrolysis. A fourier transform attenuated total reflection infrared spectroscopy and tryptophan fluorescence quenching analysis.

21 January 2018

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