Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil (Q43560244)

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English	Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil	scientific article

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scholarly article

1 reference

Europe PubMed Central

24 November 2017

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil (English)

1 reference

Europe PubMed Central

24 November 2017

multiple drug resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

24 November 2017

author name string

Clarke DM

2

1 reference

Europe PubMed Central

24 November 2017

language of work or name

0 references

publication date

14 February 2001

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Europe PubMed Central

24 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

24 November 2017

276

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Europe PubMed Central

24 November 2017

18

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Europe PubMed Central

24 November 2017

14972-14979

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Europe PubMed Central

24 November 2017

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug resistance in oncology: diagnostic and therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Novel sulfhydryl reagents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Unraveling the mechanism of the lactose permease of Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The effects of lipids and detergents on ATPase-active P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identifiers

10.1074/JBC.M100407200

1 reference

Europe PubMed Central

24 November 2017

1 reference

Europe PubMed Central

24 November 2017

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