HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage (Q40421589)

20 September 2017

HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage (English)

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20 September 2017

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4

Gabriella D'Orazi

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20 September 2017

Valeria Di Stefano

1

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20 September 2017

Silvia Soddu

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2

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20 September 2017

Ada Sacchi

series ordinal

3

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20 September 2017

language of work or name

English

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publication date

1 August 2005

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20 September 2017

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20 September 2017

24

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20 September 2017

35

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20 September 2017

5431-5442

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208717

20 September 2017

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Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

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HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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WAF1, a potential mediator of p53 tumor suppression

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

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p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

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Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

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Why is p53 acetylated?

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

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DNA damage activates p53 through a phosphorylation-acetylation cascade

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Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program

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inferred from DOI database lookup

7 January 2021

based on heuristic

NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1208717

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Dimensions Publication ID

20 September 2017

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1 reference