Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. (Q40437372)

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10 January 2020

title

Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation (English)

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10 January 2020

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8

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10 January 2020

author name string

Chiou-Feng Lin

1

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10 January 2020

Chia-Ling Chen

2

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10 January 2020

Wen-Tsan Chang

3

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10 January 2020

Ming-Shiou Jan

4

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10 January 2020

Li-Jin Hsu

5

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10 January 2020

Ren-Huang Wu

6

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10 January 2020

Yi-Ting Fang

7

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10 January 2020

Wen-Chang Chang

9

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10 January 2020

Yee-Shin Lin

10

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10 January 2020

language of work or name

English

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publication date

6 April 2005

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Journal of Biological Chemistry

10 January 2020

published in

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10 January 2020

volume

280

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issue

25

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page(s)

23758-23765

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Mitochondria and apoptosis

10 January 2020

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Bcl-2 family proteins

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

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Bcl-2 phosphorylation required for anti-apoptosis function

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A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis

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Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

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Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

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Apoptosis. A cinderella caspase takes center stage

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Bcl-2 constitutively suppresses p53-dependent apoptosis in colorectal cancer cells

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Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis.

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Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

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Bcl-2 interrupts the ceramide-mediated pathway of cell death.

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Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M412292200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15817479%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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