Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. (Q40474758)

20 September 2017

Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling. (English)

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20 September 2017

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Jörn M Schattenberg

1

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20 September 2017

Yongjun Wang

2

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20 September 2017

Rajat Singh

3

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20 September 2017

Raina M Rigoli

4

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20 September 2017

Mark J Czaja

5

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20 September 2017

language of work or name

English

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publication date

4 January 2005

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Journal of Biological Chemistry

20 September 2017

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20 September 2017

280

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20 September 2017

11

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20 September 2017

9887-9894

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Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Fatty liver, hypertension, and the metabolic syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Insulin signalling and the regulation of glucose and lipid metabolism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Cellular mechanisms of insulin resistance

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Inhibition of c-Myc expression sensitizes hepatocytes to tumor necrosis factor-induced apoptosis and necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Temperature-sensitive adult liver cell line dependent on glucocorticoid for differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Cytochrome P450 2E1 expression induces hepatocyte resistance to cell death from oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Nopp 140 shuttles on tracks between nucleolus and cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Amplification of the metallothionein-1 and metallothionein-2 genes in copper-resistant hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

NFkappaB prevents apoptosis and liver dysfunction during liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M410310200

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Modulation of the JNK pathway in liver affects insulin resistance status

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

p53 involvement in the pathogenesis of fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410310200

21 January 2018

Identifiers

DOI

10.1074/JBC.M410310200

1 reference

20 September 2017

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