Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation (Q40547989)

21 September 2017

Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation (English)

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21 September 2017

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4

Rudolph E Tanzi

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21 September 2017

Zhongcong Xie

1

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21 September 2017

Donna M Romano

series ordinal

2

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21 September 2017

Dora M Kovacs

series ordinal

3

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21 September 2017

language of work or name

English

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publication date

7 June 2004

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Journal of Biological Chemistry

21 September 2017

8

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based on heuristic

inferred from page(s)

published in

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21 September 2017

279

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21 September 2017

33

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21 September 2017

34130-34137

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New frontiers in Alzheimer's disease genetics

21 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilins are processed by caspase-type proteases.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Hypocapnia induces caspase-3 activation and increases Abeta production

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Regulation of apoptosis by presenilin 1.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

A common enzyme connects notch signaling and Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Gamma-secretase: never more enigmatic

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M401094200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Biochemistry. Intramembrane proteases--mixing oil and water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Characterization of human presenilin 1 using N-terminal specific monoclonal antibodies: Evidence that Alzheimer mutations affect proteolytic processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401094200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401094200

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21 September 2017

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