Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells (Q40595350)

21 September 2017

Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells (English)

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21 September 2017

Sarah E Golding

1

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21 September 2017

Elizabeth Rosenberg

2

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21 September 2017

Ashraf Khalil

3

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21 September 2017

Alison McEwen

4

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21 September 2017

Matthew Holmes

5

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21 September 2017

Steven Neill

6

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21 September 2017

Lawrence F Povirk

7

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21 September 2017

Kristoffer Valerie

8

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21 September 2017

language of work or name

English

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publication date

26 January 2004

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Journal of Biological Chemistry

21 September 2017

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21 September 2017

279

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21 September 2017

15

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21 September 2017

15402-15410

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Regulation and mechanisms of mammalian double-strand break repair

21 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Cellular responses to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Double-strand breaks and translocations in cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Recombinational DNA repair and human disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Homologous recombinational repair of DNA ensures mammalian chromosome stability

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Chromosomal stability and the DNA double-stranded break connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA double strand break repair in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Colworth Medal lecture. Detection, repair and signalling of DNA double-strand breaks.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

High frequency and error-prone DNA recombination in ataxia telangiectasia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

ATM: a mediator of multiple responses to genotoxic stress

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

The many substrates and functions of ATM

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Genomic instability in mice lacking histone H2AX

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Mechanism by which caffeine potentiates lethality of nitrogen mustard

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Caffeine inhibits the checkpoint kinase ATM

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

The controlling role of ATM in homologous recombinational repair of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA damage checkpoint control in cells exposed to ionizing radiation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Sensing of intermediates in V(D)J recombination by ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Human TP53 from the malignant glioma-derived cell lines M059J and M059K has a cancer-associated mutation in exon 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Lack of correlation between ATM protein expression and tumour cell radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant herpes simplex virus-thymidine kinase in combination with acyclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Construction of a recombinant adenovirus for efficient delivery of the I-SceI yeast endonuclease to human cells and its application in the in vivo cleavage of chromosomes to expose new potential telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Fragments of ATM which have dominant-negative or complementing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M314191200

Caffeine-induced radiosensitization is independent of nonhomologous end joining of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

p53-dependent G1 arrest and p53-independent apoptosis influence the radiobiologic response of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Chromosomal double-strand break repair in Ku80-deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

BRCA2 is required for homology-directed repair of chromosomal breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Detection of ATM gene mutation in human glioma cell line M059J by a rapid frameshift/stop codon assay in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

Nuclear retention of ATM at sites of DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M314191200

21 January 2018

Identifiers

DOI

10.1074/JBC.M314191200

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21 September 2017

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