Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step. (Q40613424)

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21 December 2019

title

Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step (English)

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21 December 2019

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3

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21 December 2019

Alexander Kalinkovich

4

object named as

Alexander Kalinkovich

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21 December 2019

author name string

Gadi Borkow

1

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21 December 2019

Veerappan Vijayabaskar

2

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21 December 2019

Aviva Lapidot

5

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21 December 2019

publication date

1 November 2003

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21 December 2019

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21 December 2019

volume

60

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21 December 2019

issue

3

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21 December 2019

page(s)

181-192

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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry

21 December 2019

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Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection

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The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp-120-induced death of human neuroblastoma cells.

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HIV-1 RNA dimerization initiation site is structurally similar to the ribosomal A site and binds aminoglycoside antibiotics

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Structural rearrangements of HIV-1 Tat-responsive RNA upon binding of neomycin B

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Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: implications for development of selective CXCR4 antagonists

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An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication

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Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro

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7 January 2021

Aminoglycoside-arginine conjugates that bind TAR RNA: synthesis, characterization, and antiviral activity

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7 January 2021

Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: synthesis and anti-HIV activities

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Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

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Viral phenotype and CCR5 genotype

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Interactions among HIV gp120, CD4, and CXCR4: dependence on CD4 expression level, gp120 viral origin, conservation of the gp120 COOH- and NH2-termini and V1/V2 and V3 loops, and sensitivity to neutralizing antibodies.

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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

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7 January 2021

The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

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7 January 2021

T-cell-line-tropic human immunodeficiency virus type 1 that is made resistant to stromal cell-derived factor 1alpha contains mutations in the envelope gp120 but does not show a switch in coreceptor use

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Binding of neomycin to the TAR element of HIV-1 RNA induces dissociation of Tat protein by an allosteric mechanism

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7 January 2021

Fragments of the HIV-1 Tat protein specifically bind TAR RNA.

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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.

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Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1

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Identifiers

DOI

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21 December 2019

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