Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP. (Q40685818)

22 September 2017

Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP. (English)

1 reference

amyotrophic lateral sclerosis

22 September 2017

0 references

1 reference

1 reference

Ching-Wei Cheng

1

1 reference

PubMed ID

26219309

22 September 2017

Meng-Jau Lin

series ordinal

2

1 reference

PubMed ID

26219309

22 September 2017

Che-Kun James Shen

series ordinal

3

1 reference

22 September 2017

29 July 2015

1 reference

22 September 2017

Journal of Neurogenetics

1 reference

22 September 2017

29

1 reference

22 September 2017

2-3

1 reference

22 September 2017

59-68

1 reference

Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type A

22 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Regulation of autophagy by neuropathological protein TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Regulation of TDP-43 aggregation by phosphorylation and p62/SQSTM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

The molecular links between TDP-43 dysfunction and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Nuclear factor TDP-43 can affect selected microRNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TAR DNA-binding protein 43 in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Autophagy and apoptosis dysfunction in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Control of autophagy as a therapy for neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Comparison of parallel high-throughput RNA sequencing between knockout of TDP-43 and its overexpression reveals primarily nonreciprocal and nonoverlapping gene expression changes in the central nervous system of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Transcription factor expression uniquely identifies most postembryonic neuronal lineages in the Drosophila thoracic central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

A Drosophila model for TDP-43 proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Neuronal function and dysfunction of Drosophila dTDP

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Incidence of amyotrophic lateral sclerosis in Europe

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Autophagy: process and function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Advantages and limitations of different p62-based assays for estimating autophagic activity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

State of play in amyotrophic lateral sclerosis genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

The molecular basis of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43-mediated neuron loss in vivo requires RNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Structural diversity and functional implications of the eukaryotic TDP gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Autophagy activation ameliorates neuronal pathogenesis of FTLD-U mice: a new light for treatment of TARDBP/TDP-43 proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43: an emerging new player in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01677063.2015.1077832

10.3109/01677063.2015.1077832

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

26219309