BAX and BAK mediate p53-independent suppression of tumorigenesis (Q40702714)

22 September 2017

BAX and BAK mediate p53-independent suppression of tumorigenesis (English)

1 reference

22 September 2017

Eileen White

4

0 references

author name string

Kurt Degenhardt

series ordinal

1

1 reference

PubMed ID

12242152

22 September 2017

Guanghua Chen

series ordinal

2

1 reference

PubMed ID

12242152

22 September 2017

Tullia Lindsten

series ordinal

3

1 reference

22 September 2017

1 September 2002

1 reference

22 September 2017

1 reference

22 September 2017

2

1 reference

22 September 2017

193-203

1 reference

22 September 2017

3

1 reference

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

22 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Activation and activities of the p53 tumour suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bcl-2 blocks p53-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

1 reference

7 January 2021

Bak and Bax function to limit adenovirus replication through apoptosis induction

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bax and Bak independently promote cytochrome C release from mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

p53 enhances BAK and CD95 expression in human malignant glioma cells but does not enhance CD95L-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Essential role for p53-mediated transcription in E1A-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

1 reference

7 January 2021

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

Role of BAX in the apoptotic response to anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900126-5

7 January 2021

10.1016/S1535-6108(02)00126-5

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

12242152