p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation (Q40714283)

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scientific article published on August 2002

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English	p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation	scientific article published on August 2002

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scholarly article

1 reference

Europe PubMed Central

23 September 2017

p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation (English)

1 reference

Europe PubMed Central

23 September 2017

author name string

Lynn E Horton

1

1 reference

Europe PubMed Central

23 September 2017

Martin Bushell

2

1 reference

Europe PubMed Central

23 September 2017

Diane Barth-Baus

3

1 reference

Europe PubMed Central

23 September 2017

Vivienne J Tilleray

4

1 reference

Europe PubMed Central

23 September 2017

Michael J Clemens

5

1 reference

Europe PubMed Central

23 September 2017

Jack O Hensold

6

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Europe PubMed Central

23 September 2017

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publication date

1 August 2002

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Europe PubMed Central

23 September 2017

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Europe PubMed Central

23 September 2017

21

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Europe PubMed Central

23 September 2017

5325-5334

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Europe PubMed Central

23 September 2017

34

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Europe PubMed Central

23 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205662

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Translational regulation of ribonucleotide reductase by eukaryotic initiation factor 4E links protein synthesis to the control of DNA replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Structure and function in the p53 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Continuous protein synthesis is required to maintain the probability of entry into S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53 represses ribosomal gene transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53 is a general repressor of RNA polymerase III transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells

1 reference

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21 January 2018

The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

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21 January 2018

Cytoplasmic p53 polypeptide is associated with ribosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Regulation of translation initiation by FRAP/mTOR

1 reference

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21 January 2018

p53-dependent elevation of p21Waf1 expression by UV light is mediated through mRNA stabilization and involves a vanadate-sensitive regulatory system

1 reference

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21 January 2018

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

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21 January 2018

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1 reference

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21 January 2018

Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Inducers of erythroleukemic differentiation cause messenger RNAs that lack poly(A)-binding protein to accumulate in translationally inactive, salt-labile 80 S ribosomal complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53 mutations in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

The p53 gene family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53 binds selectively to the 5' untranslated region of cdk4, an RNA element necessary and sufficient for transforming growth factor beta- and p53-mediated translational inhibition of cdk4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2alpha, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53 and tumour viruses: catching the guardian off-guard

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

eIF4E activity is regulated at multiple levels

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

The target of rapamycin (TOR) proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Regulation of PTEN transcription by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

TOR signalling and control of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

p53: death star

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and the tumor suppressor protein p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Repression of RNA polymerase I transcription by the tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

21 January 2018

Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential role for caspase-8 in transcription-independent apoptosis triggered by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Translational regulation of human p53 gene expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of eukaryotic translation in purified and semipurified systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205662

7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.ONC.1205662

1 reference

Europe PubMed Central

23 September 2017

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1 reference

Europe PubMed Central

23 September 2017

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