Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model. (Q40731929)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27036915%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

title

Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model (English)

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31 March 2020

4

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31 March 2020

Jose A. Villadangos

5

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31 March 2020

Gabriela Segal

1

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31 March 2020

author name string

Sandro Prato

2

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31 March 2020

Dietmar Zehn

3

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31 March 2020

language of work or name

English

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publication date

1 April 2016

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31 March 2020

published in

Journal of Immunology

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31 March 2020

volume

196

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issue

9

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page(s)

3935-3942

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Adoptive immunotherapy for cancer or viruses

31 March 2020

cites work

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Adoptive immunotherapy for cancer: harnessing the T cell response

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Functional differences between low- and high-affinity CD8(+) T cells in the tumor environment

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Complete but curtailed T-cell response to very low-affinity antigen

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Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.

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Autoimmunity associated with immunotherapy of cancer

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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

21 January 2018

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Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma

21 January 2018

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Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold.

21 January 2018

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T cell receptor antagonist peptides induce positive selection

21 January 2018

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Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection.

21 January 2018

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Characterization of two TCR transgenic mouse lines specific for herpes simplex virus.

21 January 2018

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Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

21 January 2018

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Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity

21 January 2018

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

21 January 2018

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T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

21 January 2018

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High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment

21 January 2018

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

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Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

21 January 2018

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Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

21 January 2018

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

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Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity

21 January 2018

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T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy

21 January 2018

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The three Es of cancer immunoediting

21 January 2018

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Neoantigens in cancer immunotherapy.

21 January 2018

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Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes

21 January 2018

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An abrupt and concordant initiation of apoptosis: antigen-dependent death of CD8+ CTL.

21 January 2018

1 reference

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Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses

21 January 2018

1 reference

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Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1502187

From TCR Engagement to T Cell Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.1502187

21 January 2018

Identifiers

DOI

10.4049/JIMMUNOL.1502187

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27036915%20AND%20SRC:MED&resulttype=core&format=json

31 March 2020

1 reference