Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. (Q40787327)

23 September 2017

Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. (English)

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23 September 2017

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H Kishi

1

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23 September 2017

K Nakagawa

2

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23 September 2017

M Matsumoto

3

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23 September 2017

M Suga

4

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23 September 2017

M Ando

5

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23 September 2017

Y Taya

6

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23 September 2017

M Yamaizumi

7

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23 September 2017

language of work or name

English

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publication date

8 August 2001

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Journal of Biological Chemistry

23 September 2017

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23 September 2017

276

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23 September 2017

42

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23 September 2017

39115-39122

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GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway

23 September 2017

1 reference

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An osmosensing signal transduction pathway in yeast.

21 January 2018

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

21 January 2018

1 reference

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Hypomorphic C4B∗ 15 variant of the fourth component of complement

21 January 2018

1 reference

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Heat shock induces transient p53-dependent cell cycle arrest at G1/S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M105134200

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M105134200

Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Nuclear accumulation of p53 in normal human fibroblasts is induced by various cellular stresses which evoke the heat shock response, independently of the cell cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Microinjection of partially purified protein factor restores DNA damage specifically in group A of xeroderma pigmentosum cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

From receptors to stress-activated MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

Stress signals utilize multiple pathways to stabilize p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105134200

21 January 2018

Identifiers

DOI

10.1074/JBC.M105134200

1 reference

23 September 2017

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