Antagonists of GPR35 display high species ortholog selectivity and varying modes of action (Q41401817)

30 September 2017

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action (English)

1 reference

30 September 2017

Stuart A Nicklin

8

0 references

author name string

Laura Jenkins

1

1 reference

30 September 2017

Nicholas Harries

2

1 reference

30 September 2017

Jennifer E Lappin

3

1 reference

30 September 2017

Amanda E MacKenzie

4

1 reference

30 September 2017

Zaynab Neetoo-Isseljee

5

1 reference

30 September 2017

Craig Southern

6

1 reference

30 September 2017

Edward G McIver

7

1 reference

30 September 2017

Debra L Taylor

9

1 reference

30 September 2017

Graeme Milligan

10

1 reference

30 September 2017

language of work or name

English

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publication date

11 September 2012

1 reference

Journal of Pharmacology and Experimental Therapeutics

30 September 2017

1 reference

30 September 2017

343

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30 September 2017

3

1 reference

30 September 2017

683-695

1 reference

GPR35 as a Novel Therapeutic Target.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Refining efficacy: allosterism and bias in G protein-coupled receptor signaling.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Orthologue selectivity and ligand bias: translating the pharmacology of GPR35.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

GPR35 is a novel lysophosphatidic acid receptor.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Molecular determinants of ligand binding to H4R species variants

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Beta-arrestins and cell signaling

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Heterotrimeric G-proteins: a short history

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Techniques: promiscuous Galpha proteins in basic research and drug discovery

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Beta 3-adrenoceptor agonists as anti-diabetic and anti-obesity drugs in humans

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Chimaeric G alpha proteins: their potential use in drug discovery

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Multiple tyrosine metabolites are GPR35 agonists

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

GPR35 is a target of the loop diuretic drugs bumetanide and furosemide

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Aspirin metabolites are GPR35 agonists.

11 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

GPR35 is a functional receptor in rat dorsal root ganglion neurons

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500541

Tyrphostin analogs are GPR35 agonists

19 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22967846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of genes related to heart failure using global gene expression profiling of human failing myocardium

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22967846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Screening G protein-coupled receptors: measurement of intracellular calcium using the fluorometric imaging plate reader

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22967846

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.112.198945

1 reference

30 September 2017

1 reference

30 September 2017

PubMed publication ID

22967846

1 reference