G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors (Q37209133)

19 August 2017

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title

G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors (English)

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19 August 2017

transmembrane protein

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Folkert Verkaar

1

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19 August 2017

Jos W G van Rosmalen

2

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19 August 2017

Marion Blomenröhr

3

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19 August 2017

Chris J van Koppen

4

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19 August 2017

W Matthijs Blankesteijn

5

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19 August 2017

Jos F M Smits

6

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19 August 2017

Guido J R Zaman

7

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19 August 2017

1 January 2008

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Biotechnology Annual Review

19 August 2017

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19 August 2017

14

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19 August 2017

253-274

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Seven-transmembrane receptors

19 August 2017

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

How many drug targets are there?

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

cAMP detection methods in HTS: selecting the best from the rest

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Techniques: high-throughput measurement of intracellular Ca(2+) -- back to basics.

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Functional G protein-coupled receptor assays for primary and secondary screening

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Mining the Wnt pathway for cancer therapeutics

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Wnt/beta-catenin-pathway as a molecular target for future anti-cancer therapeutics

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The wnt-frizzled cascade in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

G protein-coupled receptor kinases

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Role of endocytosis in mediating downregulation of G-protein-coupled receptors

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Role of G Protein-Coupled Receptor Kinases on the Agonist-Induced Phosphorylation and Internalization of the Follitropin Receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The association of arrestin-3 with the human lutropin/choriogonadotropin receptor depends mostly on receptor activation rather than on receptor phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Distinct mechanisms of agonist-induced endocytosis for human chemokine receptors CCR5 and CXCR4

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Differential beta-arrestin trafficking and endosomal sorting of somatostatin receptor subtypes

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Beta-arrestin-biased ligands at seven-transmembrane receptors

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Morphine activates opioid receptors without causing their rapid internalization

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Morphine side effects in beta-arrestin 2 knockout mice

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Identification of allosteric peptide agonists of CXCR4.

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

High content screening for G protein-coupled receptors using cell-based protein translocation assays.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Bioluminescence resonance energy transfer as a screening assay: Focus on partial and inverse agonism

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Beta galactosidase complementation: a cell-based luminescent assay platform for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Quantitative cell-based high-content screening for vasopressin receptor agonists using transfluor technology

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

High-throughput confocal microscopy for beta-arrestin-green fluorescent protein translocation G protein-coupled receptor assays using the Evotec Opera

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

High-content screening of known G protein-coupled receptors by arrestin translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The ligand-independent translocation assay: an enabling technology for screening orphan G protein-coupled receptors by arrestin recruitment

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

1 reference

7 January 2021

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS).

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Differential roles of arrestin-2 interaction with clathrin and adaptor protein 2 in G protein-coupled receptor trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Development of a BRET2 screening assay using beta-arrestin 2 mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Use of the BRET 7TM receptor/beta-arrestin assay in drug discovery and screening.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Beta galactosidase enzyme fragment complementation as a novel technology for high throughput screening

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Enzymatic detection of protein translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Epidermal growth factor receptor dimerization monitored in live cells

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Cell-Based High-Throughput Screening Assay System for Monitoring G Protein-Coupled Receptor Activation Using β-Galactosidase Enzyme Complementation Technology

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Signal transduction by the Wnt family of ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

A mechanism for Wnt coreceptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Trimeric G protein-dependent frizzled signaling in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

A critical role for endocytosis in Wnt signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Wnt signalling in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Reduced bone mineral density and hyaloid vasculature remnants in a consanguineous recessive FEVR family with a mutation in LRP5

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https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

APC mutations occur early during colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

High-content screening assay for activators of the Wnt/Fzd pathway in primary human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

A homogeneous cell-based assay to measure nuclear translocation using beta-galactosidase enzyme fragment complementation.

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Signalling by hedgehog family proteins in Drosophila and vertebrate development

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Sheep, lilies and human genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Activating Smoothened mutations in sporadic basal-cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Hedgehog signalling in cancer formation and maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Activation of heterotrimeric G proteins by Smoothened

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

The cell biology of Smo signalling and its relationships with GPCRs

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

High-throughput screening using beta-lactamase reporter-gene technology for identification of low-molecular-weight antagonists of the human gonadotropin releasing hormone receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

G-protein coupled receptor assays: to measure affinity or efficacy that is the question

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

Cryopreserved cells facilitate cell-based drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1387-2656%2808%2900010-0

7 January 2021

10.1016/S1387-2656(08)00010-0

Identifiers

DOI

1 reference

19 August 2017

1 reference