The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. (Q41498366)

1 October 2017

The Anti-Osteoanabolic Function of Sclerostin Is Blunted in Mice Carrying a High Bone Mass Mutation of Lrp5. (English)

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1 October 2017

Timur A Yorgan

1

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1 October 2017

Stephanie Peters

2

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1 October 2017

Anke Jeschke

3

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1 October 2017

Peggy Benisch

4

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1 October 2017

Franz Jakob

5

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1 October 2017

Michael Amling

6

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1 October 2017

Thorsten Schinke

7

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1 October 2017

8 June 2015

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Journal of Bone and Mineral Research

1 October 2017

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1 October 2017

30

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1 October 2017

1175-1183

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1 October 2017

7

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The way Wnt works: components and mechanism.

1 October 2017

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WNT signaling in bone homeostasis and disease: from human mutations to treatments

21 January 2018

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Wnt/β-catenin signaling and disease

21 January 2018

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21 January 2018

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An LDL-receptor-related protein mediates Wnt signalling in mice

21 January 2018

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High bone density due to a mutation in LDL-receptor-related protein 5

21 January 2018

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21 January 2018

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A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

21 January 2018

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Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

21 January 2018

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High bone mass in mice expressing a mutant LRP5 gene

21 January 2018

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Lrp5 functions in bone to regulate bone mass

21 January 2018

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Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

21 January 2018

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Essential role of beta-catenin in postnatal bone acquisition

21 January 2018

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Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis

21 January 2018

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Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

21 January 2018

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

21 January 2018

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Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling

21 January 2018

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Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

21 January 2018

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Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions

21 January 2018

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Role of sclerostin in bone and cartilage and its potential as a therapeutic target in bone diseases

21 January 2018

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

21 January 2018

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The DAN family: modulators of TGF-β signaling and beyond

21 January 2018

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Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 January 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

21 January 2018

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Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

21 January 2018

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LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.

21 January 2018

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The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations

21 January 2018

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Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome

21 January 2018

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Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity.

21 January 2018

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Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

21 January 2018

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Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function

21 January 2018

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

21 January 2018

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Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity

21 January 2018

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High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

21 January 2018

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Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner

21 January 2018

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Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice

21 January 2018

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Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin

21 January 2018

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

21 January 2018

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Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells

21 January 2018

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BoneJ: Free and extensible bone image analysis in ImageJ

21 January 2018

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Fiji: an open-source platform for biological-image analysis

21 January 2018

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Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast

21 January 2018

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

21 January 2018

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PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling.

21 January 2018

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

21 January 2018

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Drapc1 expression during mouse embryonic development.

21 January 2018

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

21 January 2018

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Lrp5 regulation of bone mass and serotonin synthesis in the gut.

21 January 2018

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Reply to Lrp5 regulation of bone mass and gut serotonin synthesis.

21 January 2018

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Romosozumab in postmenopausal women with low bone mineral density.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.2461

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1 October 2017

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