Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1. (Q41788612)

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scientific article published on 26 September 2008

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English	Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1.	scientific article published on 26 September 2008

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scholarly article

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14 January 2020

Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1 (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18820259%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Martin J. Humphries

2

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14 January 2020

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14 January 2020

author name string

Dimitra Valdramidou

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14 January 2020

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26 September 2008

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14 January 2020

Journal of Biological Chemistry

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14 January 2020

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14 January 2020

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14 January 2020

32704-32714

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14 January 2020

Functional and computational studies of the ligand-associated metal binding site of beta3 integrins

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Small molecule inhibitors of integrin alpha2beta1.

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Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut.

1 reference

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6 June 2018

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1 reference

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Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

1 reference

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Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.

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Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

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Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

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6 June 2018

Structure and allosteric regulation of the X 2 integrin I domain

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6 June 2018

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

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6 June 2018

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere

1 reference

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Integrins: bidirectional, allosteric signaling machines

1 reference

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6 June 2018

Identification of critical residues for ligand binding in the integrin beta3 I-domain by site-directed mutagenesis.

1 reference

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

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6 June 2018

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

1 reference

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Geometry of metal-ligand interactions in proteins

1 reference

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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

1 reference

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Structural basis of collagen recognition by integrin alpha2beta1

1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18820259

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based on heuristic

inferred from PubMed ID database lookup

'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18820259

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M802066200

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18820259%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18820259%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18820259%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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