Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets. (Q41809741)

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scientific article published on 13 December 2012

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English	Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.	scientific article published on 13 December 2012

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scholarly article

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20 February 2020

Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets (English)

1 reference

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20 February 2020

Samantha F Moore

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20 February 2020

Marion T J van den Bosch

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20 February 2020

Alastair W Poole

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20 February 2020

author name string

Kei Sakamoto

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13 December 2012

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20 February 2020

Journal of Biological Chemistry

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20 February 2020

288

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20 February 2020

3918-3928

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20 February 2020

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis

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6 June 2018

An important role for Akt3 in platelet activation and thrombosis

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6 June 2018

What Are the bona fide GSK3 Substrates?

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Akt signalling in health and disease.

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6 June 2018

Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes.

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6 June 2018

mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].

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6 June 2018

Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets

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6 June 2018

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

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6 June 2018

Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.

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6 June 2018

Protein kinase Calpha: disease regulator and therapeutic target.

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6 June 2018

Protein kinase C-mediated phosphorylation and activation of PDE3A regulate cAMP levels in human platelets.

1 reference

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6 June 2018

PKCalpha regulates platelet granule secretion and thrombus formation in mice

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6 June 2018

GSK3beta is a negative regulator of platelet function and thrombosis

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6 June 2018

The selectivity of protein kinase inhibitors: a further update

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6 June 2018

GSK-3 inhibitors induce chromosome instability

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6 June 2018

Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A.

1 reference

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6 June 2018

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

1 reference

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6 June 2018

Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice

1 reference

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6 June 2018

PKC-alpha regulates cardiac contractility and propensity toward heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567645

6 June 2018

Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2

1 reference

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6 June 2018

p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567645

6 June 2018

Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3567645

6 June 2018

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1 reference

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6 June 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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6 June 2018

The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells

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6 June 2018

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes

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6 June 2018

Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways

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18 August 2018

Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

1 reference

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18 August 2018

NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity

1 reference

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18 August 2018

Akt Activation in Platelets Depends on Gi Signaling Pathways

1 reference

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18 August 2018

Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?

1 reference

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18 August 2018

The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimally functional fluorescein isothiocyanate-labelled fibrinogen for quantitative studies of binding to activated platelets and platelet aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of the p110 isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual regulation of platelet protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/23239877

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.429936

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239877%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239877%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23239877%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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