Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease (Q41964540)

14 October 2017

Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease (English)

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14 October 2017

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1

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1 June 2020

Min Zhang

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1 June 2020

Baiba K. Gillard

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Henry Pownall

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1 June 2020

author name string

Ciaran M Lee

2

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1 June 2020

Yi-Hsien Yeh

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Rachel H Hsu

4

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Rajat Gupta

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Perla J Rodriguez

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Chang Seok Lee

8

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Karl-Dimiter Bissig

10

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1 June 2020

James F Martin

12

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1 June 2020

Gang Bao

13

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1 June 2020

William R Lagor

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1 June 2020

language of work or name

English

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publication date

16 March 2017

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14 October 2017

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1 June 2020

volume

7

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1 June 2020

page(s)

44624

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Creative Commons Attribution 4.0 International

1 June 2020

copyright license

start time

16 March 2017

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/srep44624

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CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

5 June 2018

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Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.

5 June 2018

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Genome engineering using the CRISPR-Cas9 system

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Therapeutic short hairpin RNA expression in the liver: viral targets and vectors

5 June 2018

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A knock-out mouse model for methylmalonic aciduria resulting in neonatal lethality

5 June 2018

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

5 June 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

5 June 2018

1 reference

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Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene

5 June 2018

1 reference

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Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat

5 June 2018

1 reference

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Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus

5 June 2018

1 reference

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Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

5 June 2018

1 reference

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Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery

5 June 2018

1 reference

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Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes

5 June 2018

1 reference

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Low plasma cholesterol levels caused by a short deletion in the apolipoprotein B gene.

5 June 2018

1 reference

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E-CRISP: fast CRISPR target site identification.

5 June 2018

1 reference

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The burden of chronic venous diseases is unknown.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

18 August 2018

1 reference

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Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

AAV vector integration sites in mouse hepatocellular carcinoma.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

Raising HDL cholesterol without inducing hepatic steatosis and hypertriglyceridemia by a selective LXR modulator

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5353616

Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28300165

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP44624

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28300165%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28300165%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference