Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition (Q42008823)

15 October 2017

Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition (English)

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15 October 2017

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whole genome duplication

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7

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15 October 2017

Lisa M Giammona

1

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15 October 2017

Swapna Panuganti

2

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15 October 2017

Jan M Kemper

3

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15 October 2017

Pani A Apostolidis

4

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15 October 2017

Stephan Lindsey

5

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15 October 2017

Eleftherios T Papoutsakis

6

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15 October 2017

26 August 2009

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15 October 2017

Experimental Hematology

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15 October 2017

37

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15 October 2017

11

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15 October 2017

1340-1352.e3

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describes a project that uses

15 October 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2763937/fullTextXML

inferred from PubMed Central ID database lookup

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5 June 2018

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Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells.

5 June 2018

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5 June 2018

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5 June 2018

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity

5 June 2018

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Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia

5 June 2018

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Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription

5 June 2018

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Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease

5 June 2018

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

5 June 2018

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Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion

5 June 2018

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5 June 2018

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Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway.

5 June 2018

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Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels

5 June 2018

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Regulation of corepressor function by nuclear NADH.

5 June 2018

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The end is just the beginning: megakaryocyte apoptosis and platelet release

5 June 2018

1 reference

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Identification of a small molecule inhibitor of Sir2p

5 June 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

5 June 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

5 June 2018

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Regulation of the G2/M transition by p53.

5 June 2018

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p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

5 June 2018

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Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis

5 June 2018

1 reference

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Incidence, cost, and outcomes of bleeding and chemotherapy dose modification among solid tumor patients with chemotherapy-induced thrombocytopenia

5 June 2018

1 reference

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The role of p53-target genes in human cancer

5 June 2018

1 reference

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Increased D-type cyclin expression together with decreased cdc2 activity confers megakaryocytic differentiation of a human thrombopoietin-dependent hematopoietic cell line.

5 June 2018

1 reference

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Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling

5 June 2018

1 reference

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

5 June 2018

1 reference

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Evaluation of cytokines for expansion of the megakaryocyte and granulocyte lineages

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763937

An improved cycling assay for nicotinamide adenine dinucleotide.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763937

Effects of estradiol on the biosynthesis of pyridine nucleotide coenzymes in the rat uterus

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2763937

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

5 June 2018

1 reference

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Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

17 August 2018

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In vitro and in vivo megakaryocyte differentiation of fresh and ex-vivo expanded cord blood cells: rapid and transient megakaryocyte reconstitution.

17 August 2018

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LC/MS analysis of NAD biosynthesis using stable isotope pyridine precursors

17 August 2018

1 reference

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Ultrastructural characterization of maturation, platelet release, and senescence of human cultured megakaryocytes

17 August 2018

1 reference

12 December 2020

Stromal cell-derived factor 1alpha increases polyploidization of megakaryocytes generated by human hematopoietic progenitor cells

1 reference

12 December 2020

Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin

1 reference

12 December 2020

Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release

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12 December 2020

Histone deacetylase inhibitors in cancer therapy

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12 December 2020

The origin of platelet count and volume

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12 December 2020

Importance of nicotinamide as an NAD precursor in the human erythrocyte

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12 December 2020

Single extraction method for the spectrophotometric quantification of oxidized and reduced pyridine nucleotides in erythrocytes

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12 December 2020

Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand

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12 December 2020

Effects of cytokines on platelet production from blood and marrow CD34+ cells

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12 December 2020

Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates

1 reference

12 December 2020

10.1016/J.EXPHEM.2009.08.004

Identifiers

DOI

1 reference

15 October 2017

1 reference

15 October 2017

PubMed publication ID

19715739

1 reference