Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (Q42081736)

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13 February 2020

title

Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia (English)

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13 February 2020

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13 February 2020

Antonio Sacco

2

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13 February 2020

Patricia Maiso

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13 February 2020

Mei-Chih Liang

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13 February 2020

Kwok Kin Wong

14

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Irene M Ghobrial

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13 February 2020

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Abdel Kareem Azab

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13 February 2020

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Feda Azab

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13 February 2020

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Judith Runnels

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13 February 2020

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Molly Melhem

1 reference

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13 February 2020

4

Costas Pitsillides

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13 February 2020

author name string

Emanuel N Husu

3

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13 February 2020

Steven Vesole

5

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13 February 2020

Hai T Ngo

9

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13 February 2020

Phong Quang

10

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13 February 2020

Charles Lin

15

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13 February 2020

language of work or name

English

0 references

publication date

19 November 2009

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13 February 2020

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13 February 2020

volume

115

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13 February 2020

issue

3

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13 February 2020

page(s)

559-569

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MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

13 February 2020

cites work

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Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-kappaB signaling pathways in Waldenstrom's macroglobulinemia

30 May 2018

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microRNA expression in the biology, prognosis, and therapy of Waldenström macroglobulinemia

30 May 2018

1 reference

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Many forks in the path: cycling with FoxO.

30 May 2018

1 reference

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Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia

30 May 2018

1 reference

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The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia

30 May 2018

1 reference

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Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma

30 May 2018

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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

30 May 2018

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The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions

30 May 2018

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Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a

30 May 2018

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Exploiting the PI3K/AKT pathway for cancer drug discovery

30 May 2018

1 reference

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In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

30 May 2018

1 reference

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Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes.

30 May 2018

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Molecular targeting: PI3 kinase pathway

30 May 2018

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

30 May 2018

1 reference

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The biology and clinical relevance of the PTEN tumor suppressor pathway

30 May 2018

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PTEN: from pathology to biology

30 May 2018

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

30 May 2018

1 reference

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Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

30 May 2018

1 reference

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

30 May 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

30 May 2018

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

30 May 2018

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

30 May 2018

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

30 May 2018

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Phosphoinositide 3-kinase signalling pathways

30 May 2018

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Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement

30 May 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

30 May 2018

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Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

30 May 2018

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PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways

30 May 2018

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

17 August 2018

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Role of the phosphatidylinositol 3'-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells.

17 August 2018

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Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

17 August 2018

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Nuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomas

1 December 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/19965685

12 December 2020

inferred from PubMed ID database lookup

AKT and cancer--is it all mTOR?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19965685

12 December 2020

inferred from PubMed ID database lookup

Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstrom macroglobulinemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19965685

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1182/BLOOD-2009-07-235747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965685%20AND%20SRC:MED&resulttype=core&format=json

release_go4b5a4wlzf65glsudggo5e3zy

13 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/go4b5a4wlzf65glsudggo5e3zy

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965685%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference