Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline (Q42131298)

17 October 2017

Loss of muscarinic M1 receptor exacerbates Alzheimer's disease-like pathology and cognitive decline (English)

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17 October 2017

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17 October 2017

David Baglietto-Vargas

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17 October 2017

Masashi Kitazawa

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17 October 2017

Antonella Caccamo

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17 October 2017

Tatiana Estrada-Hernandez

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17 October 2017

David H Cribbs

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17 October 2017

Avraham Fisher

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17 October 2017

Frank M LaFerla

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17 October 2017

language of work or name

English

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publication date

23 June 2011

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The American Journal of Pathology

17 October 2017

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17 October 2017

179

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17 October 2017

2

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17 October 2017

980-991

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describes a project that uses

17 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3157199/fullTextXML

inferred from PubMed Central ID database lookup

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Clearing the brain's amyloid cobwebs

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Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

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Differential alterations in muscarinic receptor subtypes in Alzheimer's disease: implications for cholinergic-based therapies

29 May 2018

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Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

29 May 2018

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Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure activity in mice

29 May 2018

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Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease

29 May 2018

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Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

29 May 2018

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Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation

29 May 2018

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29 May 2018

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Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

29 May 2018

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Characterization of muscarinic receptor subtypes in Alzheimer and control brain cortices by selective muscarinic antagonists

29 May 2018

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Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

29 May 2018

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Oroxylin A increases BDNF production by activation of MAPK-CREB pathway in rat primary cortical neuronal culture

29 May 2018

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Connecting TNF-alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid beta protein.

17 August 2018

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Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease

17 August 2018

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Quantitative measurement of cerebral haemodynamics in early vascular dementia and Alzheimer's disease

17 August 2018

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M1 receptors play a central role in modulating AD-like pathology in transgenic mice

17 August 2018

1 reference

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Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease

17 August 2018

1 reference

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Spatial memory in aged rats is related to PKCgamma-dependent G-protein coupling of the M1 receptor

17 August 2018

1 reference

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Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies-an immunohistochemical study

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

m1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3157199

CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet β-cells mediated by hepatocyte growth factor

17 August 2018

1 reference

12 December 2020

Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

1 reference

12 December 2020

Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells

1 reference

12 December 2020

Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion

1 reference

12 December 2020

10.1016/J.AJPATH.2011.04.041

Identifiers

DOI

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17 October 2017

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17 October 2017

PubMed publication ID

21704011

1 reference