Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor (Q42132874)

17 October 2017

Two-dimensional infrared spectroscopy reveals the complex behaviour of an amyloid fibril inhibitor (English)

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17 October 2017

infrared spectroscopy

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Chris T Middleton

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Daniel P Raleigh

object named as

Daniel P Raleigh

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Martin T. Zanni

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Martin T Zanni

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17 October 2017

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Juan J de Pablo

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17 October 2017

Peter Marek

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17 October 2017

Ping Cao

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17 October 2017

Chi-cheng Chiu

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17 October 2017

Sadanand Singh

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17 October 2017

Ann Marie Woys

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17 October 2017

11 March 2012

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17 October 2017

355-360

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https://scigraph.springernature.com/pub.10.1038/nchem.1293

17 October 2017

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2DIR spectroscopy of human amylin fibrils reflects stable β-sheet structure

29 May 2018

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29 May 2018

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29 May 2018

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Residue-specific vibrational echoes yield 3D structures of a transmembrane helix dimer

29 May 2018

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Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy

29 May 2018

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29 May 2018

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Efficient microwave-assisted synthesis of human islet amyloid polypeptide designed to facilitate the specific incorporation of labeled amino acids

29 May 2018

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Combination of kinetically selected inhibitors in trans leads to highly effective inhibition of amyloid formation

29 May 2018

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Residue-specific structural kinetics of proteins through the union of isotope labeling, mid-IR pulse shaping, and coherent 2D IR spectroscopy

29 May 2018

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Solution structures of rat amylin peptide: simulation, theory, and experiment

29 May 2018

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The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors

29 May 2018

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Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation

29 May 2018

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Strategies for extracting structural information from 2D IR spectroscopy of amyloid: application to islet amyloid polypeptide

29 May 2018

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2D IR provides evidence for mobile water molecules in beta-amyloid fibrils

29 May 2018

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Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

29 May 2018

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How to turn your pump-probe instrument into a multidimensional spectrometer: 2D IR and Vis spectroscopies via pulse shaping

29 May 2018

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Gating mechanism of the influenza A M2 channel revealed by 1D and 2D IR spectroscopies.

29 May 2018

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Couplings between peptide linkages across a 3(10)-helical hydrogen bond revealed by two-dimensional infrared spectroscopy

29 May 2018

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Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation.

29 May 2018

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The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations

29 May 2018

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Coherent two dimensional infrared spectroscopy of a cyclic decapeptide antamanide. A simulation study of the amide-I and A bands

29 May 2018

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Atomic structure of the cross-β spine of islet amyloid polypeptide (amylin)

29 May 2018

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Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40.

29 May 2018

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Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

29 May 2018

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Amide vibrations are delocalized across the hydrophobic interface of a transmembrane helix dimer.

29 May 2018

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Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

29 May 2018

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Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

29 May 2018

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Picosecond dynamics of a membrane protein revealed by 2D IR.

29 May 2018

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Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

29 May 2018

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Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

29 May 2018

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Mechanisms of amyloid fibril self-assembly and inhibition. Model short peptides as a key research tool

29 May 2018

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Inhibition of amyloid fibril formation by peptide analogues modified with alpha-aminoisobutyric acid

29 May 2018

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

29 May 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

29 May 2018

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Design and characterization of a membrane permeable N-methyl amino acid-containing peptide that inhibits Abeta1-40 fibrillogenesis

29 May 2018

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Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy

29 May 2018

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Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

29 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Melting of a beta-hairpin peptide using isotope-edited 2D IR spectroscopy and simulations.

29 May 2018

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Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

17 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Generation and characterization of phase and amplitude shaped femtosecond mid-IR pulses.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Two-dimensional infrared spectroscopy provides evidence of an intermediate in the membrane-catalyzed assembly of diabetic amyloid

17 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

17 August 2018

Escaping amyloid fate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Lipid membranes modulate the structure of islet amyloid polypeptide.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Pramlintide as an adjunct to insulin therapy improves long-term glycemic and weight control in patients with type 2 diabetes: a 1-year randomized controlled trial

17 August 2018

1 reference

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Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Beta-sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3334878

Conserved and Cooperative Assembly of Membrane-Bound α-Helical States of Islet Amyloid Polypeptide†

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCHEM.1293

Incorporation of Pseudoproline Derivatives Allows the Facile Synthesis of Human IAPP, a Highly Amyloidogenic and Aggregation-Prone Polypeptide

21 January 2018

1 reference

12 December 2020

Polymorphic Fibrillar Assembly of Human Amylin

1 reference

12 December 2020

A Simple and Economical Method for the Production of13C,18O-Labeled Fmoc-Amino Acids with High Levels of Enrichment: Applications to Isotope-Edited IR Studies of Proteins

1 reference

12 December 2020

A Single-Point Mutation Converts the Highly Amyloidogenic Human Islet Amyloid Polypeptide into a Potent Fibrillization Inhibitor

1 reference

12 December 2020

2D IR line shapes probe ovispirin peptide conformation and depth in lipid bilayers

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEM.1293

1 reference

17 October 2017

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17 October 2017

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