The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation (Q42152316)

17 October 2017

The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation (English)

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17 October 2017

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8

Ruth Nussinov

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Wenkang Huang

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Qiancheng Shen

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Shaoyong Lu

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Rong Deng

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Haiming Jiang

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17 October 2017

Huili Song

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Shuai Li

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Jianxiu Yu

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17 October 2017

Jian Zhang

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4 August 2015

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1725-1734

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describes a project that uses

17 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7734571/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase

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Allosteric regulation and catalysis emerge via a common route.

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12 December 2020

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Insulin-feedback via PI3K-C2alpha activated PKBalpha/Akt1 is required for glucose-stimulated insulin secretion

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12 December 2020

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

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Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

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An ATP-site on-off switch that restricts phosphatase accessibility of Akt

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The methionine-aromatic motif plays a unique role in stabilizing protein structure

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Allosteric post-translational modification codes

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Structural basis of AMPK regulation by small molecule activators

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Lytic water dynamics reveal evolutionarily conserved mechanisms of ATP hydrolysis by TIP49 AAA+ ATPases.

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Harnessing allostery: a novel approach to drug discovery

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Recent computational advances in the identification of allosteric sites in proteins

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The design of covalent allosteric drugs

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12 December 2020

The structural basis of ATP as an allosteric modulator

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12 December 2020

Two pathways mediate interdomain allosteric regulation in pin1

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12 December 2020

Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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12 December 2020

10.1016/J.STR.2015.06.027

Identifiers

DOI

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17 October 2017

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