Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer. (Q42153553)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25274033%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer (English)

1 reference

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20 February 2020

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3

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20 February 2020

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Sue Anne Chew

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20 February 2020

author name string

Chuandong Geng

1

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20 February 2020

Kimal Rajapakshe

2

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20 February 2020

John Shou

4

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20 February 2020

Vijay Kumar Eedunuri

5

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20 February 2020

Christopher Foley

6

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20 February 2020

Warren Fiskus

7

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20 February 2020

Mahitha Rajendran

8

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20 February 2020

Martin Zimmermann

10

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20 February 2020

Richard Bond

11

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20 February 2020

Bin He

12

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20 February 2020

Cristian Coarfa

13

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20 February 2020

Nicholas Mitsiades

14

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20 February 2020

language of work or name

English

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publication date

1 October 2014

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20 February 2020

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20 February 2020

volume

74

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20 February 2020

issue

19

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20 February 2020

page(s)

5631-5643

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Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants

20 February 2020

cites work

1 reference

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Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1

29 May 2018

1 reference

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A road map to comprehensive androgen receptor axis targeting for castration-resistant prostate cancer

29 May 2018

1 reference

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The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer

29 May 2018

1 reference

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Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

29 May 2018

1 reference

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Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression

29 May 2018

1 reference

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Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

29 May 2018

1 reference

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Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors

29 May 2018

1 reference

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Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.

29 May 2018

1 reference

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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

29 May 2018

1 reference

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The androgen receptor gene mutations database: 2012 update.

29 May 2018

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ARN-509: a novel antiandrogen for prostate cancer treatment

29 May 2018

1 reference

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Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors

29 May 2018

1 reference

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Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer

29 May 2018

1 reference

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Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1

29 May 2018

1 reference

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The genomic complexity of primary human prostate cancer

29 May 2018

1 reference

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Activation of the androgen receptor by intratumoral bioconversion of androstanediol to dihydrotestosterone in prostate cancer

29 May 2018

1 reference

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Intragenic rearrangement and altered RNA splicing of the androgen receptor in a cell-based model of prostate cancer progression

29 May 2018

1 reference

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Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

29 May 2018

1 reference

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Tubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer

29 May 2018

1 reference

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Diverse somatic mutation patterns and pathway alterations in human cancers

29 May 2018

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Integrative genomic profiling of human prostate cancer

29 May 2018

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Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

29 May 2018

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Nuclear receptor coregulators in cancer biology

29 May 2018

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Inhibition of the androgen receptor as a novel mechanism of taxol chemotherapy in prostate cancer

29 May 2018

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

29 May 2018

1 reference

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Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens.

29 May 2018

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Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy

29 May 2018

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Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

29 May 2018

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Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer

29 May 2018

1 reference

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Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

29 May 2018

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Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

29 May 2018

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Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth

29 May 2018

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Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer

29 May 2018

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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

29 May 2018

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SRC-3 is required for prostate cancer cell proliferation and survival

29 May 2018

1 reference

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The program of androgen-responsive genes in neoplastic prostate epithelium

29 May 2018

1 reference

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Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer

29 May 2018

1 reference

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Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

Inhibiting proteasomes in human HepG2 and LNCaP cells increases endogenous androgen receptor levels

29 May 2018

1 reference

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Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system

29 May 2018

1 reference

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Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

Targeting the AIB1 oncogene through mammalian target of rapamycin inhibition in the mammary gland.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

Androgen receptor mutations in prostate cancer.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4209379

Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25274033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25274033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-14-0476

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25274033%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25274033%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference