Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification (Q42434602)

31 October 2017

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification (English)

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31 October 2017

Patrick J Roberts

1

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31 October 2017

Natalia Mitin

2

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31 October 2017

Patricia J Keller

3

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31 October 2017

Emily J Chenette

4

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31 October 2017

James P Madigan

5

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31 October 2017

Rachel O Currin

6

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31 October 2017

Adrienne D Cox

7

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31 October 2017

Oswald Wilson

8

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31 October 2017

Paul Kirschmeier

9

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31 October 2017

Channing J Der

10

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31 October 2017

language of work or name

English

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publication date

9 July 2008

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31 October 2017

14

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Journal of Biological Chemistry

inferred from page(s)

published in

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31 October 2017

283

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31 October 2017

37

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31 October 2017

25150-25163

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describes a project that uses

31 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2533093/fullTextXML

inferred from PubMed Central ID database lookup

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Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

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28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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28 May 2018

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Isoprenylcysteine carboxyl methyltransferase deficiency in mice

28 May 2018

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The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements

28 May 2018

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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine

28 May 2018

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

28 May 2018

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Role of the carboxyterminal residue in peptide binding to protein farnesyltransferase and protein geranylgeranyltransferase

28 May 2018

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Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

28 May 2018

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

28 May 2018

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Novel determinants of H-Ras plasma membrane localization and transformation.

28 May 2018

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Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation

28 May 2018

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Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p

28 May 2018

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Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation

28 May 2018

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

28 May 2018

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Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid

28 May 2018

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The posttranslationally modified C-terminal structure of bovine aortic smooth muscle rhoA p21.

28 May 2018

1 reference

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Sequence dependence of protein isoprenylation

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Protein prenylation: more than just glue?

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Post-translational modifications of p21rho proteins

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2533093

Farnesyltransferase inhibitors alter the prenylation and growth-stimulating function of RhoB

16 August 2018

1 reference

12 December 2020

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

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12 December 2020

Post-prenylation-processing enzymes as new targets in oncogenesis

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12 December 2020

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

1 reference

12 December 2020

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M800882200

1 reference

31 October 2017

1 reference

31 October 2017

PubMed publication ID

18614539

1 reference