Post-prenylation-processing enzymes as new targets in oncogenesis (Q81703538)

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11 January 2020

review article

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title

Post-prenylation-processing enzymes as new targets in oncogenesis (English)

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11 January 2020

author name string

Ann M Winter-Vann

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15864282%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Patrick J Casey

series ordinal

2

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11 January 2020

publication date

1 May 2005

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11 January 2020

published in

Nature Reviews Cancer

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11 January 2020

volume

5

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11 January 2020

issue

5

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11 January 2020

page(s)

405-412

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Role of protein modification reactions in programming interactions between ras-related GTPases and cell membranes

11 January 2020

cites work

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Protein prenyltransferases

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CaaX converting enzymes

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The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

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Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases

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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

31 March 2020

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Lamins: building blocks or regulators of gene expression?

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Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules

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Prenyl-binding domains: potential targets for Ras inhibitors and anti-cancer drugs

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

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RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

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Perspectives on farnesyl transferase inhibitors in cancer therapy

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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Farnesyltransferase inhibitors: promises and realities

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Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

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Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

31 March 2020

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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

31 March 2020

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Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

31 March 2020

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Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

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Cloning and characterization of a mammalian prenyl protein-specific protease

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Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

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Substrate specificity of mammalian prenyl protein-specific endoprotease activity

31 March 2020

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Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease

31 March 2020

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Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases

31 March 2020

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The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities

31 March 2020

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On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.

31 March 2020

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Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

31 March 2020

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The Saccharomyces cerevisiae prenylcysteine carboxyl methyltransferase Ste14p is in the endoplasmic reticulum membrane

31 March 2020

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Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes

31 March 2020

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Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice

31 March 2020

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Isoprenylcysteine carboxyl methyltransferase deficiency in mice

31 March 2020

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Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

31 March 2020

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Small GTP-binding proteins

31 March 2020

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Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.

31 March 2020

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The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules

31 March 2020

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Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi

31 March 2020

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Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae

31 March 2020

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Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export

31 March 2020

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Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase

31 March 2020

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A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

31 March 2020

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Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

31 March 2020

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Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils

31 March 2020

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Discrimination between different methylation states of chemotaxis receptor Tar by receptor methyltransferase CheR.

31 March 2020

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Methylation of a membrane protein involved in bacterial chemotaxis

31 March 2020

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Assays of human postprenylation processing enzymes

31 March 2020

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Identification of an isoprenylated cysteine methyl ester hydrolase activity in bovine rod outer segment membranes

31 March 2020

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Fractionation and characterization of protein C-terminal prenyl-cysteine methylesterase activities from rabbit brain

31 March 2020

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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

31 March 2020

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Hematologic effects of inactivating the Ras processing enzyme Rce1.

31 March 2020

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Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1

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Inhibitors of the isoprenylated protein endoprotease

31 March 2020

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Selective inhibition of ras-transformed cell growth by a novel fatty acid-based chloromethyl ketone designed to target Ras endoprotease

31 March 2020

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Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate

31 March 2020

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Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine

31 March 2020

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Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis

31 March 2020

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Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation

31 March 2020

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Relationship between tissue levels of S-adenosylmethionine, S-adenosylhomocysteine, and transmethylation reactions

31 March 2020

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S-Adenosylmethionine and methylation

31 March 2020

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Prenylated protein methyltransferases do not distinguish between farnesylated and geranylgeranylated substrates

31 March 2020

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Glucose- and GTP-dependent stimulation of the carboxyl methylation of CDC42 in rodent and human pancreatic islets and pure beta cells. Evidence for an essential role of GTP-binding proteins in nutrient-induced insulin secretion

31 March 2020

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Carboxyl methylation of Ras regulates membrane targeting and effector engagement

31 March 2020

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Farnesyl analogues inhibit vasoconstriction in animal and human arteries

31 March 2020

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Farnesylcysteine analogues inhibit chemotactic peptide receptor-mediated G-protein activation in human HL-60 granulocyte membranes

31 March 2020

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Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransferase

31 March 2020

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Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease

31 March 2020

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Guilty as charged: B-RAF is a human oncogene

31 March 2020

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Signal events: Cell signal transduction and its inhibition in cancer

31 March 2020

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Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

31 March 2020

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Clinical significance of pleiotropic effects of statins: lipid reduction and beyond

31 March 2020

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Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems

31 March 2020

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Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release

31 March 2020

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Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation.

31 March 2020

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Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation

31 March 2020

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Ras signalling on the endoplasmic reticulum and the Golgi

31 March 2020

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

31 March 2020

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Intracellular localization of the P21rho proteins

31 March 2020

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