Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains (Q42454455)

31 October 2017

Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains (English)

1 reference

31 October 2017

Chuen-Pei Ng

1

1 reference

31 October 2017

Hung Chiu Lee

2

1 reference

31 October 2017

Chung Wai Ho

3

1 reference

31 October 2017

Talha Arooz

4

1 reference

31 October 2017

Wai Yi Siu

5

1 reference

31 October 2017

Anita Lau

6

1 reference

31 October 2017

Randy Y C Poon

7

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31 October 2017

language of work or name

English

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publication date

16 December 2003

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Journal of Biological Chemistry

31 October 2017

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31 October 2017

279

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31 October 2017

10

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31 October 2017

8808-8819

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https://api.crossref.org/works/10.1074%2FJBC.M312215200

31 October 2017

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Chk1 and Chk2 kinases in checkpoint control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

ATM and ATR: networking cellular responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Cell cycle checkpoint signaling through the ATM and ATR kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Serine-345 is required for Rad3-dependent phosphorylation and function of checkpoint kinase Chk1 in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Human claspin is required for replication checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Chk2 activation and phosphorylation-dependent oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Differential responses of proliferating versus quiescent cells to adriamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Cyclin F is degraded during G2-M by mechanisms fundamentally different from other cyclins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

An overactivated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Degradation of Cyclin A Does Not Require Its Phosphorylation by CDC2 and Cyclin-dependent Kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

New link in a web of human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

Nuclear exclusion of Cdc25 is not required for the DNA damage checkpoint in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312215200

21 January 2018

Identifiers

DOI

10.1074/JBC.M312215200

1 reference

31 October 2017

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