Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter (Q42712029)

5 November 2017

Detection of statin cytotoxicity is increased in cells expressing the OATP1B1 transporter (English)

1 reference

5 November 2017

Xun Zhang

1

1 reference

5 November 2017

Renato J Scialis

series ordinal

2

1 reference

5 November 2017

Bo Feng

series ordinal

3

1 reference

5 November 2017

Karen Leach

series ordinal

4

1 reference

5 November 2017

5 April 2013

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5 November 2017

Toxicological Sciences

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5 November 2017

134

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5 November 2017

1

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5 November 2017

73-82

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Trial watch: Phase II failures: 2008-2010.

5 November 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Phase III and submission failures: 2007–2010

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Membrane transporters in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Multidrug resistance in cancer: role of ATP-dependent transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Predicting in vivo safety characteristics using physiochemical properties and in vitro assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Comparative toxicity evaluation of cyanobacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Cell death assays for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

SLCO1B1 variants and statin-induced myopathy--a genomewide study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Impact of drug transporter studies on drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Uptake of rosuvastatin by isolated rat hepatocytes: comparison with pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

The expression and function of organic anion transporting polypeptides in normal tissues and in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Coexistence of passive and carrier-mediated processes in drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Phosphoprotein analysis for investigation of in vivo relationship between protein phosphatase inhibitory activities and acute hepatotoxicity of microcystin-LR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

ADMET in silico modelling: towards prediction paradise?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Targeted disruption of murine organic anion-transporting polypeptide 1b2 (Oatp1b2/Slco1b2) significantly alters disposition of prototypical drug substrates pravastatin and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

Transporter-mediated drug uptake and efflux: important determinants of adverse drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFT085

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFT085

1 reference

5 November 2017

1 reference