Coexistence of passive and carrier-mediated processes in drug transport (Q34128770)

31 July 2017

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title

Coexistence of passive and carrier-mediated processes in drug transport (English)

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31 July 2017

7

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31 July 2017

2

Manfred Kansy

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31 July 2017

Kiyohiko Sugano

1

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31 July 2017

Per Artursson

3

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31 July 2017

Alex Avdeef

4

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31 July 2017

Stefanie Bendels

5

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31 July 2017

Li Di

6

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31 July 2017

Bernard Faller

8

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31 July 2017

Holger Fischer

9

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31 July 2017

Grégori Gerebtzoff

10

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31 July 2017

Hans Lennernaes

11

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31 July 2017

Frank Senner

12

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31 July 2017

1 August 2010

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Nature Reviews Drug Discovery

31 July 2017

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31 July 2017

9

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31 July 2017

8

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31 July 2017

597-614

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https://scigraph.springernature.com/pub.10.1038/nrd3187

31 July 2017

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Implications of the dominant role of transporters in drug uptake by cells

31 March 2020

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Drug absorption by the rat jejunum perfused in situ. Dissociation from the pH-partition theory and role of microclimate-pH and unstirred layer.

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Development and evaluation of an in vitro method for prediction of human drug absorption II. Demonstration of the method suitability.

31 March 2020

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A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential

31 March 2020

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Diffusion of Small Non-Electrolytes across Liposome Membranes

31 March 2020

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Influence of chain ordering on the selectivity of dipalmitoylphosphatidylcholine bilayer membranes for permeant size and shape

31 March 2020

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Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity

31 March 2020

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The role of size and charge for blood-brain barrier permeation of drugs and fatty acids

31 March 2020

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MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

31 March 2020

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The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families.

31 March 2020

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Analysis and update of the human solute carrier (SLC) gene superfamily

31 March 2020

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In silico strategies for modeling membrane transporter function.

31 March 2020

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31 March 2020

Membrane transporters

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Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System

31 March 2020

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A new model of weak acid permeation through membranes revisited: does Overton still rule?

31 March 2020

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Monocarboxylic acid permeation through lipid bilayer membranes

31 March 2020

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Permeability of small nonelectrolytes through lipid bilayer membranes

31 March 2020

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Conditionally immortalized intestinal epithelial cells: novel approach for study of differentiated enterocytes

31 March 2020

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An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes.

31 March 2020

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PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones.

31 March 2020

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pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers.

31 March 2020

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Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model

31 March 2020

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pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells

31 March 2020

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pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H(+)-cotransport mechanism versus pH-partition hypothesis

31 March 2020

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Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

31 March 2020

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Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2)

31 March 2020

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Human intestinal permeability

31 March 2020

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Intestinal permeability and its relevance for absorption and elimination

31 March 2020

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Modeling gastrointestinal drug absorption requires more in vivo biopharmaceutical data: experience from in vivo dissolution and permeability studies in humans

31 March 2020

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Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.

31 March 2020

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Caco-2 permeability of weakly basic drugs predicted with the double-sink PAMPA pKa(flux) method.

31 March 2020

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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

31 March 2020

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Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

31 March 2020

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Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes

31 March 2020

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Absorption-excipient-pH classification gradient maps: sparingly soluble drugs and the pH partition hypothesis

31 March 2020

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PAMPA--a drug absorption in vitro model 8. Apparent filter porosity and the unstirred water layer

31 March 2020

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Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond

31 March 2020

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Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells

31 March 2020

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Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

31 March 2020

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Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

31 March 2020

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pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions.

31 March 2020

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Enhancing the hit-to-lead properties of lead optimization libraries

31 March 2020

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In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system

31 March 2020

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Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

31 March 2020

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Variability in Caco-2 and MDCK cell-based intestinal permeability assays

31 March 2020

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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

31 March 2020

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Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model

31 March 2020

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PAMPA--critical factors for better predictions of absorption

31 March 2020

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Is PAMPA a useful tool for discovery?

31 March 2020

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Permeation characteristics of a hydrophilic basic compound across a bio-mimetic artificial membrane

31 March 2020

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The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

31 March 2020

1 reference

Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor

31 March 2020

1 reference

Permeation of permanently positive charged molecules through artificial membranes--influence of physico-chemical properties

31 March 2020

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Transport of organic ions through lipid bilayers

31 March 2020

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Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model

31 March 2020

1 reference

HPLC-Based Method for Estimating the Temperature Dependence ofn-Octanol−Water Partition Coefficients

31 March 2020

1 reference

The role of an alpha-amino group on H+ -dependent transepithelial transport of cephalosporins in Caco-2 cells

31 March 2020

1 reference

Substituent contributions to the transport of substituted p-toluic acids across lipid bilayer membranes

31 March 2020

1 reference

The permeability of liposomes to nonelectrolytes. II. The effect of nystatin and gramicidin A.

31 March 2020

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Development of structure-lipid bilayer permeability relationships for peptide-like small organic molecules

31 March 2020

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Using the Golden Triangle to optimize clearance and oral absorption

31 March 2020

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Passive oral drug absorption can be predicted more reliably by experimental than computational models--fact or myth.

31 March 2020

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Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data

31 March 2020

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A practitioner's perspective of the role of quantitative structure-activity analysis in medicinal chemistry

31 March 2020

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

31 March 2020

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Prediction of oral drug absorption in humans by theoretical passive absorption model

31 March 2020

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

31 March 2020

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Mechanistic approaches to volume of distribution predictions: understanding the processes.

31 March 2020

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Molecular properties that influence the oral bioavailability of drug candidates

31 March 2020

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Correlation of human jejunal permeability (in vivo) of drugs with experimentally and theoretically derived parameters. A multivariate data analysis approach

31 March 2020

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Ionization-specific analysis of human intestinal absorption

31 March 2020

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Blood-brain barrier permeation: molecular parameters governing passive diffusion

31 March 2020

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Molecular factors influencing drug transfer across the blood-brain barrier.

31 March 2020

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ADME evaluation in drug discovery. 5. Correlation of Caco-2 permeation with simple molecular properties.

31 March 2020

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Evaluation of dynamic polar molecular surface area as predictor of drug absorption: comparison with other computational and experimental predictors

31 March 2020

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Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

31 March 2020

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P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model

31 March 2020

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Comparison of blood-brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB.

31 March 2020

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High throughput artificial membrane permeability assay for blood-brain barrier.

31 March 2020

1 reference

Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion.

31 March 2020

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Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery

31 March 2020

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A modified parallel artificial membrane permeability assay for evaluating the bioconcentration of highly hydrophobic chemicals in fish

31 March 2020

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Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors

31 March 2020

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Exploring the role of different drug transport routes in permeability screening.

31 March 2020

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Comparison of in vitro models for the prediction of compound absorption across the human intestinal mucosa

31 March 2020

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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability

31 March 2020

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Correction of permeability with pore radius of tight junctions in Caco-2 monolayers improves the prediction of the dose fraction of hydrophilic drugs absorbed by humans

31 March 2020

1 reference

High throughput prediction of oral absorption: improvement of the composition of the lipid solution used in parallel artificial membrane permeation assay

31 March 2020

1 reference

Prediction of human intestinal permeability using artificial membrane permeability

31 March 2020

1 reference

High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes

31 March 2020

1 reference

31 March 2020

1 reference

SPR Biosensor Studies of the Direct Interaction between 27 Drugs and a Liposome Surface: Correlation with Fraction Absorbed in Humans

31 March 2020

1 reference

Solid-supported lipid membranes as a tool for determination of membrane affinity: high-throughput screening of a physicochemical parameter

31 March 2020

1 reference

IAM chromatography: an in vitro screen for predicting drug membrane permeability

31 March 2020

1 reference

Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability

31 March 2020

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QSAR study on permeability of hydrophobic compounds with artificial membranes.

31 March 2020

1 reference

Drug Partitioning: Relationships between Forward and Reverse Rate Constants and Partition Coefficient

31 March 2020

1 reference

A comparison of physiochemical property profiles of development and marketed oral drugs

31 March 2020

1 reference

Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells

31 March 2020

1 reference

A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis.

31 March 2020

1 reference

Profiling drug-like properties in discovery research

31 March 2020

1 reference

Prediction of the oral absorption of low-permeability drugs using small intestine-like 2/4/A1 cell monolayers

31 March 2020

1 reference

Pharmacokinetic assessment of multiple ATP-binding cassette transporters: the power of combination knockout mice

31 March 2020

1 reference

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

31 March 2020

1 reference

Utility of Mdr1-gene deficient mice in assessing the impact of P-glycoprotein on pharmacokinetics and pharmacodynamics in drug discovery and development

31 March 2020

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Apparent lack of effect of P-glycoprotein on the gastrointestinal absorption of a substrate, tacrolimus, in normal mice

31 March 2020

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In vitro-in vivo correlation in P-glycoprotein mediated transport in intestinal absorption.

31 March 2020

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Investigation of the role of oligopeptide transporter PEPT1 and sodium/glucose cotransporter SGLT1 in intestinal absorption of their substrates using small GTP-binding protein Rab8-null mice

31 March 2020

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Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats

31 March 2020

1 reference

Pharmaceutical and pharmacological importance of peptide transporters

31 March 2020

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Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited

31 March 2020

1 reference

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

31 March 2020

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Structure-transport relationship for the intestinal small-peptide carrier: is the carbonyl group of the peptide bond relevant for transport?

31 March 2020

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Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

31 March 2020

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A comprehensive account on the role of efflux transporters in the gastrointestinal absorption of 13 commonly used substrate drugs in humans.

31 March 2020

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Impact of P-glycoprotein-mediated intestinal efflux kinetics on oral bioavailability of P-glycoprotein substrates

31 March 2020

1 reference

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability

31 March 2020

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Role of P-glycoprotein in pharmacokinetics: clinical implications

31 March 2020

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Permeability dominates in vivo intestinal absorption of P-gp substrate with high solubility and high permeability

31 March 2020

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Role of P-glycoprotein-mediated secretion in absorptive drug permeability: An approach using passive membrane permeability and affinity to P-glycoprotein

31 March 2020

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Influence of passive permeability on apparent P-glycoprotein kinetics.

31 March 2020

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Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport

31 March 2020

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A novel screening strategy to identify ABCB1 substrates and inhibitors

31 March 2020

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Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study.

31 March 2020

1 reference

Mechanism of multidrug resistance in relation to passive membrane permeation

31 March 2020

1 reference

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system

31 March 2020

1 reference

Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug

31 March 2020

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The effect of particle size on the absorption of digoxin

31 March 2020

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An integrated model for determining causes of poor oral drug absorption.

31 March 2020

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What kinds of substrates show P-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine

31 March 2020

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Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs

31 March 2020

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Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter

31 March 2020

1 reference

Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models

31 March 2020

1 reference

The role of passive transbilayer drug movement in multidrug resistance and its modulation

31 March 2020

1 reference

The role of permeability in drug ADME/PK, interactions and toxicity--presentation of a permeability-based classification system (PCS) for prediction of ADME/PK in humans

31 March 2020

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Transporters--the view from industry

31 March 2020

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Transporters in absorption, distribution, and elimination

31 March 2020

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The role of transporters in the pharmacokinetics of orally administered drugs

31 March 2020

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Transport characteristics of fexofenadine in the Caco-2 cell model

31 March 2020

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The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique

31 March 2020

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Intestinal drug transporter expression and the impact of grapefruit juice in humans

31 March 2020

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Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers

31 March 2020

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Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability

31 March 2020

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Decrease in intracellular concentration causes the shift in Km value of efflux pump substrates.

31 March 2020

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Model analysis of the concentration-dependent permeability of P-gp substrates

31 March 2020

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Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium

31 March 2020

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Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

31 March 2020

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Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice

31 March 2020

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Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

31 March 2020

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Transporter-mediated intestinal absorption of fexofenadine in rats

31 March 2020

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Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine

31 March 2020

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Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans

31 March 2020

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Integration of preclinical and clinical data with pharmacokinetic modeling and simulation to evaluate fexofenadine as a probe for hepatobiliary transport function

31 March 2020

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The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.

31 March 2020

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Cimetidine bioavailability and variable renal clearance

31 March 2020

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Pharmacokinetics of cimetidine in advanced cirrhosis

31 March 2020

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Bioavailability and pharmacokinetics of cimetidine

31 March 2020

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Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

31 March 2020

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Isolation of a family of organic anion transporters from human liver and kidney

31 March 2020

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Human jejunal permeability of two polar drugs: cimetidine and ranitidine

31 March 2020

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Biowaiver monographs for immediate release solid oral dosage forms: cimetidine

31 March 2020

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Mechanisms of clinically relevant drug interactions associated with tacrolimus

31 March 2020

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Tacrolimus oral bioavailability doubles with coadministration of ketoconazole

31 March 2020

1 reference

Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

31 March 2020

1 reference

The role of ABC transporters in drug resistance, metabolism and toxicity

31 March 2020

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Improvement of oral drug treatment by temporary inhibition of drug transporters and/or cytochrome P450 in the gastrointestinal tract and liver: an overview

31 March 2020

1 reference

Intestinal drug transporters: in vivo function and clinical importance.

31 March 2020

1 reference

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

31 March 2020

1 reference

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

31 March 2020

1 reference

Effects of intestinal CYP3A4 and P-glycoprotein on oral drug absorption--theoretical approach

31 March 2020

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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut.

31 March 2020

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Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

31 March 2020

1 reference

Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules

31 March 2020

1 reference

The pharmacokinetics of epirubicin and docetaxel in combination in rats

31 March 2020

1 reference

Site-specific contribution of proton-coupled folate transporter/haem carrier protein 1 in the intestinal absorption of methotrexate in rats.

31 March 2020

1 reference

The effect of L-leucine on the absorption of levodopa, studied by regional jejunal perfusion in man.

31 March 2020

1 reference

Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1.

31 March 2020

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Toward an increased understanding of the barriers to colonic drug absorption in humans: implications for early controlled release candidate assessment

31 March 2020

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Presentation of a structurally diverse and commercially available drug data set for correlation and benchmarking studies

31 March 2020

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Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

31 March 2020

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Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs

31 March 2020

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Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches

31 March 2020

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Structure-activity relationship of P-glycoprotein substrates and modifiers.

31 March 2020

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Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

31 March 2020

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Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro

31 March 2020

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A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

31 March 2020

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

31 March 2020

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Transporters as a determinant of drug clearance and tissue distribution

31 March 2020

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Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

31 March 2020

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Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance

31 March 2020

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Prediction of human pharmacokinetics - renal metabolic and excretion clearance

31 March 2020

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Current industrial practices of assessing permeability and P-glycoprotein interaction

31 March 2020

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Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.

31 March 2020

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5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.

31 March 2020

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Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

31 March 2020

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Physiologically based pharmacokinetic modeling to predict transporter-mediated clearance and distribution of pravastatin in humans

31 March 2020

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31 March 2020

Black lipid membranes

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Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption

31 March 2020

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Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients

31 March 2020

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Effect of cholesterol on molecular transport of organic cations across liposome bilayers probed by second harmonic generation

31 March 2020

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The relationship between permeant size and permeability in lipid bilayer membranes

31 March 2020

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Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

31 March 2020

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

31 March 2020

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Polar molecular surface properties predict the intestinal absorption of drugs in humans.

31 March 2020

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A novel design of artificial membrane for improving the PAMPA model

31 March 2020

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P-glycoprotein-mediated efflux as a major factor in the variance of absorption and distribution of drugs: modulation of chemotherapy resistance

31 March 2020

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12 December 2020

Taxol transport by human intestinal epithelial Caco-2 cells.

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12 December 2020

A new interpretation of salicylic acid transport across the lipid bilayer: implications of pH-dependent but not carrier-mediated absorption from the gastrointestinal tract

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12 December 2020

A pH-dependent, carrier-mediated transport system for the folate analog, amethopterin, in rat jejunum

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12 December 2020

Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight

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12 December 2020

Fatty acid uptake and metabolism in a human intestinal cell line (Caco-2): comparison of apical and basolateral incubation.

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12 December 2020

Membrane permeability and lipophilicity in the isolated perfused rat liver: 5-ethyl barbituric acid and other compounds

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12 December 2020

Intestinal surface acid microclimate in vitro and in vivo in the rat

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12 December 2020

On the mechanism of intestinal absorption of drugs

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12 December 2020

How does P-glycoprotein recognize its substrates?

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12 December 2020

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine

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12 December 2020

Modulation of the permeability of H2 receptor antagonists cimetidine and ranitidine by P-glycoprotein in rat intestine and the human colonic cell line Caco-2.

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12 December 2020

Lipophilicity and drug activity

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12 December 2020

Parallel artificial membrane permeability assay (PAMPA) combined with a 10-day multiscreen Caco-2 cell culture as a tool for assessing new drug candidates

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12 December 2020

Identifiers

DOI

10.1038/NRD3187

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31 July 2017

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