Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology (Q42716028)

5 November 2017

title

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology (English)

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5 November 2017

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Rebecca I Erickson

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Jacqueline Tarrant

2

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Gary Cain

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Sock-Cheng Lewin-Koh

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Noel Dybdal

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Harvey Wong

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Elizabeth Blackwood

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Kristina West

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Ronald Steigerwalt

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Michael Mamounas

10

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John A Flygare

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Kenjie Amemiya

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Donna Dambach

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Wayne J Fairbrother

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Dolores Diaz

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publication date

5 September 2012

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5 November 2017

published in

Toxicological Sciences

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volume

131

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issue

1

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page(s)

247-258

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Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma.

5 November 2017

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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

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21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFS265

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5 November 2017

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