IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer (Q24292870)

Baculoviral IAP repeat containing 2

Europe PubMed Central

title

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer (English)

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main subject

inflammation

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Baculoviral IAP repeat containing 3

GOA release 2020-03-11

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regulation of cysteine-type endopeptidase activity

GOA release 2020-03-11

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GOA release 2020-03-11

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Mads Gyrd-Hansen

1

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Pascal Meier

object named as

Pascal Meier

series ordinal

2

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language of work or name

English

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publication date

August 2010

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published in

Nature Reviews Cancer

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volume

10

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issue

8

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page(s)

561-74

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cites work

The Hallmarks of Cancer

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IAP-targeted therapies for cancer

31 March 2020

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The inhibitors of apoptosis (IAPs) as cancer targets

31 March 2020

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

31 March 2020

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

31 March 2020

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Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

31 March 2020

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Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo.

31 March 2020

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Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

31 March 2020

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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

31 March 2020

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IAP regulation of metastasis

31 March 2020

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X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

31 March 2020

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31 March 2020

IAPs: what's in a name?

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Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat

31 March 2020

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

31 March 2020

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

31 March 2020

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

31 March 2020

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Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

31 March 2020

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Crystal Structure of the BIR1 Domain of XIAP in Two Crystal Forms

31 March 2020

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

31 March 2020

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

31 March 2020

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

31 March 2020

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Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors

31 March 2020

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XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

31 March 2020

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Mechanisms of caspase activation and inhibition during apoptosis

31 March 2020

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Human caspases: activation, specificity, and regulation

31 March 2020

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

31 March 2020

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X-linked IAP is a direct inhibitor of cell-death proteases

31 March 2020

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Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia.

31 March 2020

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

31 March 2020

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Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

31 March 2020

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A single BIR domain of XIAP sufficient for inhibiting caspases

31 March 2020

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Upstream regulatory role for XIAP in receptor-mediated apoptosis

31 March 2020

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X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

31 March 2020

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Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis.

31 March 2020

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X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

31 March 2020

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Characterization of XIAP-deficient mice

31 March 2020

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Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.

31 March 2020

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Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

31 March 2020

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Structural basis of caspase-7 inhibition by XIAP

31 March 2020

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Structural basis for the inhibition of caspase-3 by XIAP

31 March 2020

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XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

31 March 2020

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Mechanism of XIAP-mediated inhibition of caspase-9

31 March 2020

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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

31 March 2020

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Regulation of apoptosis by XIAP ubiquitin-ligase activity

31 March 2020

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cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation

31 March 2020

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A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1.

31 March 2020

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The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

31 March 2020

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The Drosophila caspase DRONC is regulated by DIAP1

31 March 2020

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Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1.

31 March 2020

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The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC.

31 March 2020

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The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

31 March 2020

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Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

31 March 2020

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Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination

31 March 2020

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Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.

31 March 2020

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Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim

31 March 2020

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Dissection of DIAP1 functional domains via a mutant replacement strategy.

31 March 2020

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Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways

31 March 2020

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Inactivation of effector caspases through nondegradative polyubiquitylation

31 March 2020

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Regulation of the Drosophila apoptosome through feedback inhibition

31 March 2020

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The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.

31 March 2020

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Ubiquitin-mediated regulation of apoptosis

31 March 2020

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The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing

31 March 2020

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Nonresolving inflammation

31 March 2020

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Immunity, Inflammation, and Cancer

31 March 2020

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NF-kappaB: linking inflammation and immunity to cancer development and progression

31 March 2020

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Integrating cell-signalling pathways with NF-kappaB and IKK function

31 March 2020

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Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

31 March 2020

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A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling.

31 March 2020

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Ubiquitylation in innate and adaptive immunity.

31 March 2020

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The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

31 March 2020

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An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila.

31 March 2020

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Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

31 March 2020

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Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling

31 March 2020

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Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis.

31 March 2020

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XIAP mediates NOD signaling via interaction with RIP2

31 March 2020

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XIAP regulates cytosol-specific innate immunity to Listeria infection

31 March 2020

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Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis

31 March 2020

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The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes

31 March 2020

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A novel role for XIAP in copper homeostasis through regulation of MURR1

31 March 2020

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X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

31 March 2020

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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

31 March 2020

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A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

31 March 2020

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

31 March 2020

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Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

31 March 2020

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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

31 March 2020

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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

31 March 2020

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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

31 March 2020

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

31 March 2020

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

31 March 2020

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

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Asymmetric recruitment of cIAPs by TRAF2

31 March 2020

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Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation

31 March 2020

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TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

31 March 2020

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Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo

31 March 2020

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Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival

31 March 2020

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TNF-alpha induces two distinct caspase-8 activation pathways

31 March 2020

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Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling

31 March 2020

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RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

31 March 2020

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

31 March 2020

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Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

31 March 2020

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

31 March 2020

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

31 March 2020

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Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1

31 March 2020

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

31 March 2020

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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

31 March 2020

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

31 March 2020

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Shared principles in NF-kappaB signaling

31 March 2020

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Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

31 March 2020

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The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting

31 March 2020

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Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

31 March 2020

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Constitutive activation of nuclear factor-kappaB is preferentially involved in the proliferation of basal-like subtype breast cancer cell lines

31 March 2020

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Constitutive non-canonical NFkappaB signaling in pancreatic cancer cells

31 March 2020

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Structural basis of IAP recognition by Smac/DIABLO

31 March 2020

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Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

31 March 2020

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

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Down-regulation of c-FLIP Enhances death of cancer cells by smac mimetic compound

31 March 2020

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Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer

31 March 2020

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Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

31 March 2020

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SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

31 March 2020

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A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

31 March 2020

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Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.

31 March 2020

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Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

31 March 2020

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MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression

31 March 2020

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

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c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

31 March 2020

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Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

31 March 2020

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The role of myeloid cells in the promotion of tumour angiogenesis

31 March 2020

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

31 March 2020

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TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion

31 March 2020

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A cytokine-mediated link between innate immunity, inflammation, and cancer

31 March 2020

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Cancer-related inflammation

31 March 2020

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Gastrointestinal lymphoma: where morphology meets molecular biology

31 March 2020

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Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

31 March 2020

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NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation

31 March 2020

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

31 March 2020

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

31 March 2020

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Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation

31 March 2020

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A dual role for the API2 moiety in API2-MALT1-dependent NF-kappaB activation: heterotypic oligomerization and TRAF2 recruitment

31 March 2020

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Pattern recognition receptors and inflammation

31 March 2020

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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines

31 March 2020

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Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

31 March 2020

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Bone marrow microenvironment and the identification of new targets for myeloma therapy

31 March 2020

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Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.

31 March 2020

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XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

31 March 2020

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Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library

31 March 2020

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Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

31 March 2020

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A unified model for apical caspase activation

31 March 2020

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Lucifer's labyrinth--ten years of path finding in cell death

31 March 2020

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Genetic control of programmed cell death in Drosophila

31 March 2020

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The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling

31 March 2020

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Ras promotes cell survival in Drosophila by downregulating hid expression

31 March 2020

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

31 March 2020

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The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein

31 March 2020

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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

31 March 2020

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Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition

31 March 2020

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Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

31 March 2020

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Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

31 March 2020

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Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization.

31 March 2020

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12 December 2020

Clinically distinct subgroups of glioblastoma multiforme studied by comparative genomic hybridization.

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12 December 2020

An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs

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12 December 2020

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

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12 December 2020

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

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12 December 2020

Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo.

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12 December 2020

Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila

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12 December 2020

The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7

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12 December 2020

Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells

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12 December 2020

Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.

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12 December 2020

Structural Basis of Caspase Inhibition by XIAP

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12 December 2020

Identifiers

DOI

10.1038/NRC2889

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

912017

1029088561

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912017

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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