Innate immunity in Alzheimer's disease (Q38358574)

2 September 2017

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title

Innate immunity in Alzheimer's disease (English)

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2 September 2017

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2

Douglas T Golenbock

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2 September 2017

Michael T Heneka

1

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2 September 2017

Eicke Latz

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

1 March 2015

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2 September 2017

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2 September 2017

16

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2 September 2017

229-236

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2 September 2017

3

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https://scigraph.springernature.com/pub.10.1038/ni.3102

2 September 2017

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cites work

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21 January 2018

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The genetics of Alzheimer disease: back to the future

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Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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The curli nucleator protein, CsgB, contains an amyloidogenic domain that directs CsgA polymerization

21 January 2018

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Role of Escherichia coli curli operons in directing amyloid fiber formation

21 January 2018

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Polymerizing the fibre between bacteria and host cells: the biogenesis of functional amyloid fibres.

21 January 2018

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Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease

21 January 2018

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In-vivo measurement of activated microglia in dementia

21 January 2018

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Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [¹¹C]DAA1106.

21 January 2018

1 reference

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

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Alzheimer's disease genetics: from the bench to the clinic

21 January 2018

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TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation

21 January 2018

1 reference

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

21 January 2018

1 reference

MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease

21 January 2018

1 reference

The effects of MyD88 deficiency on exploratory activity, anxiety, motor coordination, and spatial learning in C57BL/6 and APPswe/PS1dE9 mice

21 January 2018

1 reference

CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation.

21 January 2018

1 reference

Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

21 January 2018

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Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease.

21 January 2018

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Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

21 January 2018

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In vivo human amyloid imaging

21 January 2018

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ATP mediates rapid microglial response to local brain injury in vivo

21 January 2018

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Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.

21 January 2018

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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

21 January 2018

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Activation and regulation of the inflammasomes

21 January 2018

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

21 January 2018

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Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase

21 January 2018

1 reference

Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging

21 January 2018

1 reference

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

21 January 2018

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Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease

21 January 2018

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Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline.

21 January 2018

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Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

21 January 2018

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Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease

21 January 2018

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Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice.

21 January 2018

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Synaptic pruning by microglia is necessary for normal brain development

21 January 2018

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Immune modulation of learning, memory, neural plasticity and neurogenesis

21 January 2018

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Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system

21 January 2018

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Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists.

21 January 2018

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Beta-amyloid-mediated inhibition of NMDA receptor-dependent long-term potentiation induction involves activation of microglia and stimulation of inducible nitric oxide synthase and superoxide.

21 January 2018

1 reference

Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology

21 January 2018

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Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein

21 January 2018

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CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease.

21 January 2018

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Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia

21 January 2018

1 reference

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

The role of microglia in amyloid clearance from the AD brain

21 January 2018

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Regulation of tau pathology by the microglial fractalkine receptor

21 January 2018

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Inflammation induced by infection potentiates tau pathological features in transgenic mice

21 January 2018

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

21 January 2018

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Accumulation of tau induced in neurites by microglial proinflammatory mediators

21 January 2018

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Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model

21 January 2018

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Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

21 January 2018

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Mrp14 deficiency ameliorates amyloid β burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing.

21 January 2018

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Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases.

21 January 2018

1 reference

CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice

21 January 2018

1 reference

Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia

21 January 2018

1 reference

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

21 January 2018

1 reference

Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse

21 January 2018

1 reference

Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling

21 January 2018

1 reference

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

21 January 2018

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Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

21 January 2018

1 reference

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

21 January 2018

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

21 January 2018

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Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

21 January 2018

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

21 January 2018

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Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

21 January 2018

1 reference

Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease

21 January 2018

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PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

21 January 2018

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Changes in the brain catecholamines in patients with dementia of Alzheimer type.

21 January 2018

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

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Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

21 January 2018

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Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes

21 January 2018

1 reference

Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice.

21 January 2018

1 reference

NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits

21 January 2018

1 reference

Microglia activation in sepsis: a case-control study

21 January 2018

1 reference

Systemic inflammation and disease progression in Alzheimer disease

21 January 2018

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Long-term cognitive impairment and functional disability among survivors of severe sepsis

21 January 2018

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Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

21 January 2018

1 reference

TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects

21 January 2018

1 reference

Inflammation and Alzheimer's disease: possible role of periodontal diseases

21 January 2018

1 reference

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

21 January 2018

1 reference

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease.

21 January 2018

1 reference

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25689443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25689443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25689443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.3102

1 reference

Dimensions Publication ID

2 September 2017

0 references

1 reference