Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. (Q42915550)

11 November 2017

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. (English)

1 reference

11 November 2017

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Nicholas Barlow

3

1 reference

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2 June 2020

Nicholas Veldhuis

5

1 reference

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2 June 2020

Martina Kocan

7

1 reference

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2 June 2020

author name string

Peishen Zhao

1

1 reference

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2 June 2020

TinaMarie Lieu

2

1 reference

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2 June 2020

Matthew Metcalf

4

1 reference

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2 June 2020

Silvia Sostegni

8

1 reference

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2 June 2020

Vera Baraznenok

10

1 reference

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2 June 2020

Ian Henderson

11

1 reference

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2 June 2020

Erik Lindström

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Raquel Guerrero-Alba

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Eduardo E Valdez-Morales

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Wolfgang Liedtke

15

1 reference

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2 June 2020

Peter McIntyre

16

1 reference

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2 June 2020

Stephen J Vanner

17

1 reference

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2 June 2020

Christoph Korbmacher

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Nigel W Bunnett

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Dane D Jensen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

language of work or name

English

0 references

publication date

12 August 2014

1 reference

Journal of Biological Chemistry

11 November 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

289

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

issue

39

1 reference

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2 June 2020

page(s)

27215-27234

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist

2 June 2020

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Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).

27 May 2018

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The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

27 May 2018

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27 May 2018

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Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

27 May 2018

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Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.

27 May 2018

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Matrix metalloproteases and PAR1 activation

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Transient receptor potential vanilloid 4 blockade protects against experimental colitis in mice: a new strategy for inflammatory bowel diseases treatment?

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Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

27 May 2018

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27 May 2018

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Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins

27 May 2018

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Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.

27 May 2018

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Microglial signalling mechanisms: Cathepsin S and Fractalkine

27 May 2018

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Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

27 May 2018

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Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice

27 May 2018

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Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)

27 May 2018

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A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.

27 May 2018

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Activation of the TRPV4 ion channel is enhanced by phosphorylation.

27 May 2018

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The liberation of fractalkine in the dorsal horn requires microglial cathepsin S.

27 May 2018

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Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site

27 May 2018

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Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs).

27 May 2018

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Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2.

27 May 2018

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27 May 2018

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Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

27 May 2018

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Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain

27 May 2018

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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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27 May 2018

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Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor

27 May 2018

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Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis

16 August 2018

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Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia.

16 August 2018

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16 August 2018

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Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.

16 August 2018

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16 August 2018

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16 August 2018

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Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes.

16 August 2018

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An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

16 August 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.599712

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25118282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of transient receptor potential vanilloid 4 in rat joint inflammation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25118282

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M114.599712

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25118282%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

PubMed publication ID

25118282

1 reference