Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation. (Q42948871)

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scientific article published on 8 October 2009

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English	Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.	scientific article published on 8 October 2009

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9 February 2020

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation (English)

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Magdalena Chrzanowska-Wodnicka

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Simone M Schoenwaelder

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Stewart O. Sage

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Shaun P Jackson

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Karen Gilio

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9 February 2020

Imke C A Munnix

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Pierre Mangin

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Judith M E M Cosemans

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Marion A H Feijge

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Paola E J van der Meijden

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9 February 2020

Servé Olieslagers

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Rivka Lillian

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Johan W M Heemskerk

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8 October 2009

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9 February 2020

Journal of Biological Chemistry

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9 February 2020

33750-33762

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9 February 2020

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

1 reference

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Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

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Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets

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PI 3-kinase p110beta: a new target for antithrombotic therapy

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Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

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Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2

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Platelet-collagen interaction: is GPVI the central receptor?

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Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo

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Cell signaling by receptor tyrosine kinases

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A collagen-related peptide regulates phospholipase Cgamma2 via phosphatidylinositol 3-kinase in human platelets

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

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Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

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Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets.

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Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

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Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin alpha2beta1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3,4,5-trisphosphate triggers platelet aggregation by activating Ca2+ influx

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inter-individual variability in Ca2+ signalling in platelets from healthy volunteers: effects of aspirin and relationship with expression of endomembrane Ca2+-ATPases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen

1 reference

https://pubmed.ncbi.nlm.nih.gov/19815551

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.048439

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9 February 2020

1 reference

Europe PubMed Central

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9 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19815551%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

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