Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice (Q43228471)

16 November 2017

Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice (English)

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16 November 2017

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6

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G E Koehl

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M Spitzner

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J Ousingsawat

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R Schreiber

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16 November 2017

E K Geissler

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16 November 2017

language of work or name

English

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publication date

7 December 2009

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29

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10

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1553-1560

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https://scigraph.springernature.com/pub.10.1038/onc.2009.435

16 November 2017

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cites work

Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

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Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice

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Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells

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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

21 January 2018

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

21 January 2018

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A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

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APC, signal transduction and genetic instability in colorectal cancer

21 January 2018

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Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.435

Comparison of sirolimus plus tacrolimus versus sirolimus plus cyclosporine in high-risk renal allograft recipients: results from an open-label, randomized trial

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.435

Dosing of rapamycin is critical to achieve an optimal antiangiogenic effect against cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.435

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

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21 January 2018

Ion channels and cancer

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https://api.crossref.org/works/10.1038%2FONC.2009.435

Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice

21 January 2018

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ApcMin: A mouse model for intestinal and mammary tumorigenesis

21 January 2018

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Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia

21 January 2018

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Upregulation of colonic ion channels in APC ( Min/+ ) mice

21 January 2018

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Role of voltage-gated potassium channels in cancer.

21 January 2018

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Oncogenic potential of EAG K(+) channels

21 January 2018

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Ca2+ signaling, intracellular pH and cell volume in cell proliferation

21 January 2018

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Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells

21 January 2018

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Voltage-gated K+ channels support proliferation of colonic carcinoma cells

21 January 2018

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Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

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Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice.

21 January 2018

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Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit

21 January 2018

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Potassium channels, proliferation and G1 progression

21 January 2018

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Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity.

21 January 2018

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Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma

21 January 2018

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Control of Ion Transport in Mouse Proximal and Distal Colon by Prolactin

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.435

Development of de novo cancer in p53 knock-out mice is dependent on the type of long-term immunosuppression used

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2009.435

VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.435

Activity of voltage-gated K+ channels is associated with cell proliferation and Ca2+ influx in carcinoma cells of colon cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.435

31 March 2020

Identifiers

DOI

10.1038/ONC.2009.435

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Dimensions Publication ID

16 November 2017

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